基因多态性检测在5-氟尿嘧啶治疗胃癌患者中的应用  

Application of gene polymorphism detection in gastric cancer patient receiving 5-fluorouracil therapy

作　　者：张蕊[1] 李平利[1] 陈克广[1] 刘焕君[1] 郭曦[1] 常萍[1] 高海青[1] 郭瑞臣[1] 

机构地区：[1]山东大学齐鲁医院临床药理科,济南250012

出　　处：《中国临床药理学杂志》2016年第24期2297-2299,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家"重大新药创制"科技重大专项"十二五"第二批基金资助项目(2012ZX09303016-003);山东省自然科学基金资助项目(ZR2012HM071)

摘　　要：目的探讨基因多态性检测在5-氟尿嘧啶临床治疗效应评价中的作用。方法收集1例胃癌患者用5-氟尿嘧啶治疗后的临床疗效和药物不良反应等相关信息,检测相关基因多态性,并分析其在临床治疗中的作用。结果该患者二氢嘧啶脱氢酶(DPD)基因检测位点均为野生型;亚甲基四氢叶酸还原酶(MTHFR)基因检测位点则均为突变杂合型,MTHFR活性降低,叶酸代谢异常,5-氟尿嘧啶敏感性增加;ABCB1 3435位点基因型为TT突变纯合型,易引起严重腹泻,且具有较高淋巴转移风险。结论基因多态性检测有助于制订和调整给药方案,实现个体化治疗。Objective To explore the importance of gene polymorphism detection of 5 - fluorouracil （5 - FU） in clinical therapy. Methods The basic information and clinical data of a gastric cancer patient after administration of 5 -FU was collected, and the related gene polymor- phism was detected. Results The gene type of dihydropyrimidine dehy- drogenase （DPD） was wild. The gene type of methylenetetrahydrofolate reductase （MTHFR） was mutation heterozygous type and its activity decreased, the metabolism of folic acid was disorder and the 5 - FU sensi- tivity of patient increased. The gene type of ABCB1 3435 was mutation homozygotic type, the incidence of serious diarrhea and lymphatic metas- tasis risk increased. Conclusion The gene polymorphism determination of 5 -FU was helpful to formulate and realize the individualized treatment. regulate the dosage regimen and

关 键 词：5-氟尿嘧啶 基因多态性检测 胃癌 

分 类 号：R979.1[医药卫生—药品]