阿司匹林/壳聚糖聚集体的形成和释放行为  

Application of the aggregates of citric acid/chitosan working as the carrier of aspirin

作　　者：李扬[1] 王仲妮[1] 

机构地区：[1]山东师范大学化学化工与材料科学学院,化学成像功能探针协同创新中心,山东济南250014

出　　处：《中国海洋药物》2016年第6期72-78,共7页Chinese Journal of Marine Drugs

基　　金：国家自然科学基金项目(31271933,31071603)资助

摘　　要：目的探究阿司匹林对壳聚糖聚集体形成的影响以及阿司匹林/壳聚糖聚集体对阿司匹林的释放性能。方法选用浓度为0.25mol/L和0.3mol/L的柠檬酸溶解壳聚糖并绘制柠檬酸/壳聚糖/温度二元相图。利用阿司匹林与壳聚糖构筑聚集体并进行稳态扫描,测定其流变性质。选用壳聚糖质量分数为2.5%和5.0%的聚集体作为阿司匹林的药物载体进行体外释放,对释放过程进行动力学拟合。结果稳态流变表明阿司匹林/壳聚糖聚集体有较强的假塑性。释放实验中,阿司匹林的释放过程符合一级动力学方程,通过对空白样品对比,4组聚集体对阿司匹林均有缓释效果。结论利用阿司匹林与柠檬酸溶解的壳聚糖构筑的聚集体对药物阿司匹林有着良好的缓释效果。其中柠檬酸浓度为0.3mol/L,壳聚糖质量百分数为5.0%的聚集体包载阿司匹林时,达到最大释放量的时间为10h。Objective To explore the effect of citric acid on the formation of chitosan,and the effect of aggregates of aspirin/chitosan on aspirin＇s releasing properties.Methods chosen 0.25mol/L and 0.3mol/L citric acid respectively to dissolve chitosan and painted binary phase diagram of temperature vs chitosan.Carried out Steady-state scanning with the use of the aggregates of aspirin/chitosan and tested its rheological properties,and chose chitosan＇s aggregates respectively whose mass fraction was 2.5% and5.0% working as the carrier of aspirin to release in vitro,and then,conducted dynamic fitting for release process.Results Steady-state rheology showed that the aggregates of aspirin/chitosan had strong pseudo-plasticity.In the release test,the release process conformed to pseudo first-order model,and by comparing with the blank sample,it showed that the four groups of chitosan all acted to help aspirin dilute slower.Conclusion The chitosan aggregates constructed with aspirin with citric acid played an active role to slow down the dilution of aspirin.The best case was the aggregates of citric acid with the concentration of 0.3mol/L and chitosan with the mass fraction of 5.0%.This scenario extended the time of maximum-amount of release to 10 h.

关 键 词：壳聚糖 柠檬酸 聚集体 阿司匹林 药物缓释 

分 类 号：R971.1[医药卫生—药品]