手机辐射对脑葡萄糖代谢影响的18F-FDG PET/CT显像研究  

Evaluation of effect of mobile phone radiation on cerebral glucose metabolism using 18F-FDG PET/ CT imaging

作　　者：唐坤[1] 郑祥武[1] 林洁[1] 殷薇薇[1] 王志强[1] 陈杨宗[1] 林信实 邓渊鸿 

机构地区：[1]温州医科大学附属第一医院PET/CT室,325000

出　　处：《中华核医学与分子影像杂志》2016年第6期512-515,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：温州市科技计划项目（2013S0424）

摘　　要：目的 通过18F-FDG PET/CT显像，探讨手机辐射对脑葡萄糖代谢的影响。方法 招募健康青年志愿者20名，其中男13名，女7名，年龄（31.6±7.6）岁。按随机数字表法将其分为对照组和试验组（各10名）。对照组再分为空白对照（C1）组和模拟通话对照（C2）组；试验组分为通话时长30 min（E1）组和通话时长60 min（E2）组。注射18F-FDG前2～5 min进入模拟或通话试验状态，注射后60 min行脑PET/CT显像，测量左右两侧额叶、顶叶、颞叶、枕叶皮质SUVmax及SUVmean，采用两样本t检验或配对t检验、单因素方差分析比较各组内及组间左、右两侧不同区域脑皮质的葡萄糖代谢情况。结果 对照组左右两侧额叶、顶叶、颞叶、枕叶皮质SUVmax及SUVmean比较，差异均无统计学意义（t值：－1.933～－0.216，均P〉0.05）；E1组和E2组右侧颞叶皮质SUVmean分别为8.89±0.11、9.04±0.14，SUVmax分别为11.27±0.29、11.35±0.41，均较左侧（8.32±0.42、8.62±0.50、10.28±0.56、10.49±0.70）增高（t值：－2.924、－2.641、－3.483、－2.379，均P〈0.05），余皮质葡萄糖代谢左右两侧差异均无统计学意义。试验组右侧颞叶皮质SUVmean及SUVmax较对照组明显增高（F＝7.319、5.703，均P〈0.01）；E2组较E1组右侧颞叶葡萄糖代谢增高，但差异无统计学意义（t＝－1.591、－0.437，均P〉0.05）。结论 手机长时间持续通话产生的辐射致使邻近颞叶脑组织葡萄糖代谢增加，且随通话时间的延长其影响增加。Objective To analyze the effect of mobile phone radiation on regional cerebral glucose metabolism using 18F-FDG PET/CT imaging.Methods Twenty volunteers （13 males, 7 females; average age （31.6±7.6） years） were recruited in this study and randomly divided into control group （n=10） and experimental group （n=10） using random number table method. The control group included blank （C1） subgroup and simulate communication （C2） subgroup, and the experimental group included 30 min communication （E1） subgroup and 60 min communication （E2） subgroup. Simulate or experimental communication started 2-5 min before intravenous injection of 18F-FDG and brain PET/CT images were acquired 60 min after the injection. The SUVmax, SUVmean of bilateral frontal, parietal, temporal, occipital cortices were measured. Differences of glucose metabolism were compared using two-sample t test or paired t test, one-way analysis of variance.Results The glucose metabolism of left frontal, parietal, temporal, occipital cortices in control group was not significantly different from that of the right cortices （t： -1.933 to -0.216, all P〉0.05）. The SUVmean of right temporal cortex in E1 and E2 subgroups were 8.89±0.11, 9.04±0.14, respectively, which were statistically higher than those of the left temporal lobe （8.32±0.42, 8.62±0.50; t=-2.924, -2.641, both P〈0.05）. The similar differences were also found in SUVmax between different sides of temporal cortex in E1 and E2 subgroups （11.27±0.29 vs 10.28±0.56, 11.35±0.41 vs 10.49±0.70; t=-3.483, -2.379, both P〈0.05）. The SUVmax, SUVmean of the right temporal lobe in experimental groups were higher than those in control groups （F=7.319, 5.703, both P〈0.01）. The glucose metabolism （SUVmax, SUVmean） of right temporal cortex in E2 subgroup was higher than that of E1 subgroup, but there was no significant difference （t=-1.591, -0.437, both P〉0.05）.Conclusion The adjacent cerebral glucose metabolism can be increased by long-term mobile

关 键 词：脑 辐射 便携式电话 体层摄影术 发射型计算机 体层摄影术 x线计算机 脱氧葡萄糖 

分 类 号：R817.4[医药卫生—影像医学与核医学]