内关穴埋针疗法对慢性心肌缺血模型猪心电图改变的影响  

Effect of Needle Embedded in Neiguan (PC6) on Changes of ECG in Chronic Myocardial Ischemia Model Mini-pigs

作　　者：方继良[1] 周晟芳[2,3] 刘欢[1] 陈刚 张金铃[5] 佟海滨[1] 何勋[5] 赵青[1] 张今朝[1] 柳桂勇 洪洋[1] 高寅秋[6] 贾术勇 荣培晶[5] 

机构地区：[1]中国中医科学院广安门医院放射科,北京100053 [2]中国中医科学院广安门医院心内科,北京100053 [3]北京市隆福医院内科,北京100010 [4]内蒙古赤峰市林西县中蒙医院中医科,内蒙古125250 [5]中国中医科学院针灸研究所,北京100700 [6]中国中医科学院广安门医院麻醉科,北京100053

出　　处：《中国中西医结合杂志》2016年第12期1470-1473,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：科技部重点课题(973项目):经穴效应循经特异性靶器官响应的生物学基础研究(No.2012CB518503);国家自然科学基金面上项目(No.81273674)

摘　　要：目的观察内关穴埋针对心肌缺血模型猪心电图改变的影响。方法 12头猪采用手术放置蛋白缩窄环于冠脉前降支近段法制备动物模型,造模过程中死亡1头,4周时形成慢性心肌缺血猪模型。将造模成功的11头猪按随机数字表法分为实验组(6头)和对照组(5头)。实验组和对照组造模4周后,分别在内关穴、足三里穴埋针,在埋针2周前后,分别两次电针刺激各组对应穴位20min。观察两组造模前后和电针前后心电图Q电压值、心率和ST-T时长变化。结果与本组造模前比较,造模后两组Q电压绝对值均增加(P<0.05,P<0.01),心率比较,差异无统计学意义(P>0.05);与本组电针干预前比较,实验组ST-T时间延长(P<0.05);与对照组同期比较,实验组电针前Q电压绝对值减少(P<0.05),电针后ST-T时间延长(P<0.05),心率差异无统计学意义(P>0.05)。结论埋针内关穴可能通过改善心脏整体供血水平,达到治疗心肌缺血的作用。Objective To observe the effect of needle embedded in Neiguan（PC6）on electrocardiogram（ECG）changes in model mini-pigs with chronic myocardial ischemia.Methods The protein shrink narrow ring（Ameroid Ring）was placed in the proximal part of the left coronary anterior descending branch of 12 Chinese mini-pigs to prepare animal model.One died during the modeling.Chronic myocardial ischemia mini-pig models were established after 4 weeks.Successfully modeled 11 mini-pigs were divided into the test group（n=6）and the control group（n=5）.Needle were embedded in Neiguan（PC6）of the test group and Zusanli（ST36）of the control group at week4 after modeling.Electroacupuncture（EA）at corresponding acupoint twice（once before embedding and at week2 after embedding）,20 min each time.Changes of Q wave of ECG,heart rate,and ST-T interval were observed in the two groups before and after modeling,before and after EA.Results Compared with before modeling in the same group,the absolute value of Q wave both increased in the two groups after modeling（P〈0.05,P〈0.01）.No statistical difference existed in heart rate in the two groups between before and after modeling（P〈0.05）.Compared with before needling in the same group,ST-T interval was prolonged in the test group（P〈0.05）.Compared with the control group at the same time point,the absolute value of Q wave was reduced before EA,ST-T interval was prolonged after EA in the test group（P〈0.05）.No statistical difference existed in heart rate between the control group and the test group before EA（P〈0.05）.Conclusion Needle embedded in Neiguan（PC6）could arrive at therapeutic effect of myocardial ischemia possibly through improving myocardial blood supply.

关 键 词：内关穴 针刺 心电图 中华小型猪 慢性心肌缺血 

分 类 号：R245[医药卫生—针灸推拿学] R-332[医药卫生—中医临床基础]