可溶性人基质裂解素2与肺源性心脏病患者心肌酶学指标、炎性指标及传统心血管危险因素的相关性研究  

Correlations between sST2 and Myocardial Enzyme Indicators,Inflammatory Indicators and Traditional Cardiovascular Risk Factors in Patients with Pulmonary Heart Disease

作　　者：李生浩[1] 李杰[2] 肖怡[1] 周宇航[1] 徐肇元 闫俊芳[1] 付菲[1] 杜映荣[1] 

机构地区：[1]云南省昆明市第三人民医院心血管内科,650041 [2]云南省昆明市第三人民医院社区卫生服务中心

出　　处：《实用心脑肺血管病杂志》2016年第11期10-14,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：昆明市官渡区科技局"社会发展与科技惠民计划"基金资助项目(官科计字2015S01号)

摘　　要：目的探讨可溶性人基质裂解素2(sST2)与肺源性心脏病(肺心病)患者心肌酶学指标、炎性指标及传统心血管危险因素的相关性。方法选取昆明市第三人民医院2016-01-01—2016-03-31收治的肺心病患者51例作为病例组,另选取同期体检健康者27例作为对照组。比较两组受试者心肌酶学指标、炎性指标、传统心血管危险因素及氨基末端脑钠肽前体(NT-proBNP)、sST2水平,并分析sST2水平与心肌酶学指标、炎性指标及传统心血管危险因素的相关性。结果两组受试者肌酸激酶(CK)、肌红蛋白(Mb)、心肌肌钙蛋白T(c Tn T)水平比较,差异无统计学意义(P>0.05);病例组患者肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、超敏C反应蛋白(hs-CRP)、降钙素原(PCT)、NT-proBNP、sST2水平高于对照组(P<0.05)。两组受试者收缩压、舒张压、平均动脉压、入院时随机血糖、空腹血糖(FPG)、糖化血红蛋白(HbA_(1c))及高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平比较,差异无统计学意义(P>0.05);病例组患者总胆固醇(TC)和三酰甘油(TG)水平低于对照组(P<0.05)。Pearson相关性分析结果显示,sST2与CK-MB(r=0.582)、Mb(r=0.517)、NT-proBNP(r=0.453)呈正相关,与TC(r=-0.559)呈负相关(P<0.05)。结论 sST2与肺心病患者CK-MB、Mb、NT-proBNP、TC有关。Objective To explore the correlations between sST2 and myocardial enzyme indicators, inflammatory indicators and traditional cardiovascular risk factors in patients with pulmonary heart disease. Methods A total of 51 patients with pulmonary heart disease were selected as case group in the Third People＇s Hospital of Kunming from 2016 -01 -01 to 2016 -03 -31, a total of 27 healthy individuals were selected as control group at the same time. Myocardial enzyme indicators, inflammatory indicators, traditional cardiovascular risk factors, levels of NT-proBNP and sST2 were compared between the two groups, correlations between sST2 level and myocardial enzyme indicators, inflammatory indicators and traditional cardiovascular risk factors were compared. Results No statistically significant differences of CK, Mb or cTnT was found between the two groups （P 〉 0. 05 ） , while CK-MB, LDH, hs-CRP, PCT, NT-proBNP and sST2 of case group were statistically significantly higher than those of control group （ P 〈 0. 05 ）. No statistically significant differences of SBP, DBP, MAP, random blood glucose at admission, FPG, HbAIo, HDL-C or LDL-C was found between the two groups （ P 〉 0.05 ） , while TC and TG of case group were statistically significantly lower than those of control group （ P 〈 0. 05 ）. Pearson correlation analysis results showed that, sST2 was positively correlated with CK-MB （r =0. 582） , Mb （r =0. 517） and NT-proBNP （r =0. 453） , respectively, was negatively correlated with TC （ r = - 0. 559, P 〈 0. 05 ）. Conclusion sST2 has certain correlations with CK-MB, Mb, NT-proBNP and TC of patients with pulmonary heart disease.

关 键 词：肺源性心脏病 可溶性人基质裂解素2 心肌酶学 炎症 心血管疾病 危险因素 

分 类 号：R541.5[医药卫生—心血管疾病]