中药控缓释制剂多成分整体受控的超分子机制探讨  

Investigation on supramolecular mechanism of multi-component overall control in Chinese medicine controlled sustainedrelease preparation

作　　者：杨岩涛[1,2,3,4,5] 陶叶琴 唐闻汉 李森[1,4,5] 石继连[1,3,4] 周逸群[1,4] 刘文龙[1,2,3,4] 贺福元[1,2,3,4,5] 

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]湖南省"十二五"省级药学重点学科,湖南长沙410208 [3]中药成药性与制剂制备湖南省重点实验室,湖南长沙410208 [4]湖南中医药大学中药饮片与制剂超分子技术工程实验室,湖南长沙410208 [5]湖南中医药大学中医药超分子机理与数理特征化实验室,湖南长沙410208

出　　处：《中国中药杂志》2016年第24期4675-4679,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81073142;81173558;81573691;81270055);湖南省教育厅优秀青年基金项目(2015B172);湖南省教育厅一般项目(2015C1039);湖南省中医药科研基金项目(201494);湖南省"十二五"省级药学重点学科(1007)开放基金项目

摘　　要：控缓释制剂是创新药物的重要来源,但由于中药成分复杂,理化性质体现表观性等一系列关键问题尚未完全廓清,故真正成熟上市、能体现中药精髓的复方控缓释制剂基本没有,限制了中药控缓释制剂的研发。结合中药复方用药多成分协同作用的特点,通过对中药复方控缓释制剂制备过程中的一系列瓶颈问题的分析,结合多成分"整体受控、同步溶蚀"的中药控缓释制剂制备指导原则,在前期利用超分子化学诠释中医药理论的基础上,借鉴单成分精确控制技术,运用超分子化学理论,系统探讨中药缓控释制剂多成分整体受控的超分子机制,阐明中药复方多成分体系中超分子体存在所带来的影响,探讨中药控缓释制剂多成分整体受控、同步释放的超分子机制,为中药复方缓控释制剂的研制与开发提供有益的学术参考和借鉴,进而为制备中药控缓释制剂奠定理论与技术基础。Controlled sustained-release preparation （CSRP） is a definitely important source of innovative medicines, however, its further researches and development are limited due to the complexity of Chinese medicine （CM） compositions, and a series of unclear key problems like the apparent properties from physical and chemical aspects. Combined with the CM characteristics of the multiple components and synergistic effect, a series of bottleneck problems in the preparation of CSRP were analyzed. Then the mechanism and influences of supermoleeular chemical theory in the CSRP about the multiple-components overall-control were explored under the guide- line of ＂overall control, synchronous dissolution＂ in CSRP, based on the previous explications about supramolecular chemistry theories and with the application of single component precision controlling technologies. The supermolecular mechanism of multi-component overall control and synchronous release of the CSRP was investigated, providing an useful academic reference for the research and de- velopment of the CSRP and laying the theoretical and technieal foundation for the manufacturing process of CSRP.

关 键 词：中药 多成分 控缓释制剂 超分子 印迹模板 整体受控 

分 类 号：R283.6[医药卫生—中药学]