Nrf2与NF-κB信号交互作用介导妇科虚寒证氧化损伤研究  

Research on Oxidative Stress in Gynecological Asthenia-cold Syndrome Via a Interaction between Nrf2 and NF-κB Signal

作　　者：徐丁洁 徐洪 董玉山 杜晨光 曹颖 白素芬 柳月娟 杜惠兰[2] 

机构地区：[1]华北理工大学,河北唐山063000 [2]河北中医学院,河北石家庄050091

出　　处：《辽宁中医药大学学报》2016年第12期87-90,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然基金项目(81503451);河北省自然基金项目(H2014209172);唐山市科技支撑项目(14130221a);华北理工大学博士科研启动基金项目(35757199)

摘　　要：寒证为八纲之一,而妇科寒证是临床较为多见的病证之一,其主要病因为感受寒邪,临证有实寒证、虚寒证之分。目前对妇科虚寒证的研究主要集中在能量代谢、免疫功能,其中氧化应激损伤是妇科虚寒证较为特异的指标之一,内源性保护体系Nrf2/HO-1信号和NF-κB介导的凋亡信号在氧化应激损伤中发挥了正-反两方面的调控作用。该文一方面总结既往对妇科虚寒证的生物学机制研究,另一方面,挖掘氧化损伤尤其是Nrf2与NF-κB信号调控妇科虚寒证的作用,望对今后的研究提供新思路。Cold syndrome is one of the eight principal syndromes and gynecological asthenia-cold syndrome is more common disease in clinical. The main disease because of feeling cold. Clinically it can be divided into gynecological excess-cold syndrome and asthenia-cold syndrome. Research on themechanism of asthenia-cold syndrome is mainly in pelvic microcirculation,energy metabolism and immune function at present. And oxidative stress could be a specific marker of gynecological astheniacold syndrome. Nrf2/HO-1 signal is known to orchestrate antioxidant and detioxidant response to NF-κB signal in oxidative stress.In this paper,on the one hand,summarizes previous biology mechanism of gynecological asthenia-cold syndrome,on the other hand,digging oxidative damage especially Nrf2 and NF-κB signal regulation role of gynecological asthenia-cold syndrome,hope to provide new ideas for future research.

关 键 词：妇科虚寒证 氧化损伤 Nrf2信号 NF-κB信号 

分 类 号：R271.1[医药卫生—中医妇科学]