黏附侵袭性大肠杆菌在炎症性肠道疾病中的作用  

Role of Adherent- Invasive Escherichia coli in Inflammatory Bowl Disease

作　　者：杨玉倩[1,2] 夏芃芃[1,2] 龚卫娟[3] 朱国强[1,2] 

机构地区：[1]扬州大学兽医学院,江苏扬州225009 [2]江苏省动物重要疫病与人兽共患病防控协同创新中心,江苏扬州225009 [3]扬州大学医学院,江苏扬州225009

出　　处：《生物技术通讯》2016年第6期851-859,共9页Letters in Biotechnology

基　　金：国家自然科学基金(30571374;30771603;31072136;31270171);科技部转基因生物新品种培育重大专项(2014ZX08006-001B);江苏高校优势学科建设工程

摘　　要：哺乳动物肠道中定植有数以亿计的微生物菌群,这些菌群大多和宿主共生共演化,其中一部分在与其他微生物菌群竞争中,利用自身生存策略,促进自身的增殖复制。近期研究表明,微生物菌群平衡的破坏更有利于条件致病菌发挥作用。以宿主黏附侵袭性大肠杆菌(AIEC)为例,在肠道菌群失衡的情况下,AIEC不仅能够提高肠道炎症的发病率,还能诱发更为严重的炎症性肠炎。我们简要综述了AIEC在炎症性肠道疾病中的作用,并对炎症性肠道疾病的治疗新策略做相关展望。There are billions of microorganisms colonizing in mammalian gut, and most of them are commensals.Under the circumstance of competition from other microbiota, some of the commensals could promote replicationand survival via some specific ways. Recent studies reveal that the disturbance of microflora balance favors theemergence and function of opportunistic pathogens. Taking adherent-invasive Escherichia coli（AIEC） as an exam-ple, it could increase the incidence of gut inflammation and induce even more serious inflammatory bowl disease（IBD）. This review will mini-summarized the function of AIEC in triggering IBD, and give some prospects in newtreatment for it.

关 键 词：黏附侵袭性大肠杆菌 炎症性肠道疾病 免疫 菌群平衡 

分 类 号：R378.2[医药卫生—病原生物学]