单核细胞增生李斯特菌感染所致炎症反应性疾病的研究进展  

Research Progeress on Inflammatory Diseases Caused by Listeria monocytogenes

作　　者：孙亚薇 徐鹏[1] 平政[1] 常玉梅[1] 

机构地区：[1]解放军第二五二医院中心实验室,河北保定071000

出　　处：《生物技术通讯》2016年第6期884-887,共4页Letters in Biotechnology

基　　金：解放军第二五二医院科研课题项目(2013252yy59)

摘　　要：单核细胞增生李斯特菌（单增李斯特菌）是一种广泛存在于自然界的典型剧毒性食源性病原体,它可穿越血脑屏障、肠道屏障及胎盘屏障,导致免疫功能低下的人群,尤其是新生儿、老年人、体质虚弱、或怀孕个体发生一系列严重疾病,包括脑膜炎、脑炎、败血症、自发感染性流产等,病死率高达20%~30%。单增李斯特菌主要通过其毒力因子内化素或溶血素O等侵入并感染宿主细胞。在感染过程中,单增李斯特菌能够引发免疫细胞之间一系列复杂的相互作用,并导致感染部位发生炎症反应。我们对单增李斯特菌感染导致炎症反应性疾病的种类及发病机理方面的研究进展做简要综述。Listeria monocytogenes is a typical virulent food borne pathogen, which is widely existed in nature. Itcan pass through the blood-brain barrier, the intestinal barrier and the placenta barrier, and cause a series of dis-eases such as meningitis, encephalitis, sepsis, and spontaneous abortion among immunosuppressed patients, especial-ly newborn babies, elderly people or the pregnant individuals. L.monocytogenes invades and infects host cellsthrough virulence factors such as internalin and listeriolysin O（LLO）. During the process of infection, it can causea series of complex interaction between immune cells, thus leading to inflammatory reaction at the infection sites.This paper mainly focused on the types and pathogenesis of inflammatory diseases caused by the infection of L.monocytogenes.

关 键 词：单核细胞增生李斯特菌 溶血素O 内化素 流产 炎症反应性疾病 

分 类 号：R378[医药卫生—病原生物学]