GC-MS分析金丝梅药渣高温甲醇解聚液化产物  

GC-MS Analysis of Methanol Depolymerization Liquefied Product of Hypericum patulum Thunb.Residue in High Temperature

作　　者：段静雨 王昱博[2] 何平[3] 张春平[1,3] 李岩 么焕开 

机构地区：[1]徐州医科大学药学院江苏,徐州221004 [2]吉林大学临床医学院,长春130021 [3]西南大学生命科学学院/三峡库区生态环境教育部重点实验室,重庆400715

出　　处：《西南大学学报（自然科学版）》2016年第12期28-33,共6页Journal of Southwest University(Natural Science Edition)

基　　金：国家自然科学基金项目(81302744;31300222);江苏省自然科学基金项目(BK20130214);江苏省高校自然科学研究项目(13KJB180025);江苏省新药研究与临床药学重点实验室主任基金项目(ZR-XY201401)

摘　　要：采用GC-MS分析金丝梅药渣在高温甲醇条件下的解聚液化产物.金丝梅药渣高温甲醇解聚产物所含成分复杂,GC-MS分析共鉴定出116种化合物.化合物的类型主要有酯类、酮类、酚类、苯类、含氮类及其它类化合物,酯类化合物相对质量分数最高,为43.35%,共47种,大部分是甲酯类化合物,其中棕榈酸甲酯(No.95)的相对质量分数最高,达4.48%.甲醇参与了金丝梅药渣高温甲醇解聚反应,同时存在酯化反应和高温萃取作用,金丝梅药渣的高温解聚反应的机理有待更深入的研究.该研究结果为金丝梅化学成分研究及药渣的进一步利用提供了科学依据.The methanol depolymerization liquefied products of Hypericum patulum Thunb. residue in high temperature were analyzed with GC-MS. The result showed that it contained complex constituents and 116 compounds including esters, ketones, phenols, benzenes, nitrogen compounds and others were i- dentified with GC-MS. The number of methyl ester compounds was 47 and its relative content was 43.35%. Most of them were methyl ester compounds and palmitic acid methyl ester （No. 95） had the high- est relative content of 4.48%. Methanol was involved in high temperature depolymerization reaction of Hypericurn patulum Thunb. residue. Esterification reaction and supercritical fluid extraction function were also existed at the same time. The mechanism of high temperature depolymerization reaction of Hy- pericum patulum Thunb. residue needed to be further study. This results offered a scientific basis for chemical constituents study and further residue utilization of Hypericum patulum Thunb..

关 键 词：金丝梅药渣 解聚反应 GC-MS分析 棕榈酸甲酯 

分 类 号：R284.2[医药卫生—中药学]