MSCT灌注联合MVD测定对孤立性NSCLC病理分级的临床价值研究  

Application Values of Microvessel-slice Spiral Computed Tomography (CT) Perfusion Plus Microvessel Density Measurement in Evaluating Pathologic Grading of Solitary Non-small Cell Lung Cancer

作　　者：王宗盛[1] 袁刚[1] 周胜利[1] 

机构地区：[1]江苏省连云港市第一人民医院放射科,222002

出　　处：《医学理论与实践》2016年第24期3309-3311,共3页The Journal of Medical Theory and Practice

基　　金：江苏省自然科学基金资助项目(SBK201122841)

摘　　要：目的:探讨多层螺旋CT(Microvessel-slice spiral CT,MSCT)灌注成像参数联合微血管密度(Microvessel density MVD)测定对孤立性非小细胞肺癌(NSCLC)患者病灶分化程度的诊断价值。方法:回顾经病理证实的46例肺部孤立性NSCLC患者治疗前的病灶MSCT灌注结果,统计其灌注测定参数,与术后MVD测定值比较,分析肿瘤组织不同病理分化程度之间差异。结果:全部患者中,血容量(BV)在NSCLC的高、中、低分化程度鉴别中及毛细血管通透性(PS)在高、低分化鉴别中差异具有统计学意义(P<0.05),其中以BV值差异最大;不同分化程度的NSCLC患者MVD差异存在统计学意义,血流量(BF)、BV、PS与MVD呈正相关,平均通过时间(MTT)无明确相关性。结论:MSCT灌注成像可定量反映活体肺部病变血管生成状况,对术前判断NSCLC病灶分化程度具有参考价值。Objective：To investigate the application values of microvessel-slice spiral computed tomography （MSCT） perfusion imaging plus microvessel density （MVD） measurement in evaluating the differentiation degrees of solitary non-small cell Iung cancer （sNSCLC）. Methods.. The MSCT perfusion test results of 46 NSCLC patients confirmed by surgery and clinical pathology were retrospectively analyzed for the statistics of blood flow （BF）, blood volume （BV）, mean transit time （MTT）, and permeability surface （PS） ~then compared with the postoperative MVD measurement re- sults to analyze the differences between the CT perfusion parameters and MVD in the tumor tissues with different dif- ferentiation degrees. Results.. Among the 46 NSCLC cases, BV showed statistical significance in identifying high, mod- erate, and poor differentiation degrees of NSCLC, and PS showed statistical significance in identifying high and poor differentiation degrees（P〈0. 05）, in which BV had the maximum difference. There existed the statistically significant difference of MVD in different differentiation degrees of NSCLC; BF, BV, and PS were positively correlated with MVD. Conclusion： MSCT perfusion imaging could indirectly reflect the angiogenesis of lung lesions in vivo, thus exhibiting reference values for the preoperative determination of the differentiation degrees of NSCLC.

关 键 词：非小细胞肺癌 X线计算机 灌注成像 微血管密度 

分 类 号：R445[医药卫生—影像医学与核医学]