2010-2014年卢龙县5岁以下婴幼儿腹泻星状病毒流行特征分析  

Epidemiological characteristics of astrovirus induced diarrhea in children under 5 years old in Lulong County,2010-2014

作　　者：于秋丽[1] 刘莹莹[1] 赵文娜[1] 谢赟[1] 苏通[1] 齐顺祥[1] 

机构地区：[1]河北省疾病预防控制中心,河北石家庄050021

出　　处：《实用预防医学》2017年第1期52-54,共3页Practical Preventive Medicine

基　　金：河北科技计划项目(No.14277761D)

摘　　要：目的研究卢龙县婴幼儿腹泻患者星状病毒流行病学特点和基因型别。方法收集2010-2014年卢龙县儿童医院及妇幼保健院5岁以下腹泻住院患儿粪便标本,采用RT-PCR法检测星状病毒,并对部分PCR阳性标本进行测序鉴定基因型。结果 1 880份粪便标本检测出星状病毒阳性标本47份,检出率为2.5%,年龄分布为0~47月龄,87.2%感染者的年龄在24月龄以下;发病以冬季多见,2-5月阳性检出率较高,在4.23%~5.61%之间,部分核酸阳性标本经序列分析鉴定为HastV-1。结论星状病毒是卢龙县婴幼儿腹泻的重要病原,呈现明显的寒冷季节高发的流行趋势,HAstV-1为该地区的流行毒株。Objective To study the epidemiological features and genotypes of human astrovirus （HastV） in young children with diarrhea in Lulong County. Methods Fecal specimens were collected from children with diarrhea under 5 years of age hospitalized in the Children＇s Hospital of Lulong County and Maternal and Child Health Hospital of Lulong County from 2010 to 2014. HastV was tested by RT-PCR, some PCR-positive samples were sequenced, and then the genotypes were identified. Results HastV was detected in 47 of 1,880 specimens, with the detection rate of 2.5%. The age of the inflicted children ranged from 0 to 47 months, and 87.2% of the children were younger than 24 months. Most of the cases occurred in winter, the positive detection rates were found to be higher from February to May （ 4.23%-5.61% ）. Some PCR amplicons sequenced were identified to be HastV -1. Conclusions HastV is an important etiologic agent contributing to diarrhea in young children in Lulong County in 2010- 2014. An obvious trend of high prevalence in the cold season is present, and HastV-1 is the local prevalent strain.

关 键 词：星状病毒 病毒性腹泻 基因型别 

分 类 号：R723.11[医药卫生—儿科]