三种泡沫敷料在小鼠全层缺损创面修复中的应用效果比较  

Comparative study on the application effect of three kinds of foam dressings in wound healing of mice with full-thickness defects

作　　者：彭静[1] 徐瑞[2] 余强芳[3] 

机构地区：[1]重庆市精神卫生中心女病区,401147 [2]第三军医大学西南医院烧伤研究所,重庆400038 [3]第三军医大学新桥医院心外科重症监护室,重庆400037

出　　处：《中华现代护理杂志》2016年第29期4203-4206,共4页Chinese Journal of Modern Nursing

摘　　要：目的评价三种常用的市售泡沫敷料在皮肤护理创面修复中的效果及可行性。方法BALB／C小鼠30只随机分为三组，于小鼠背部制备直径1cm全层皮肤缺损创面，小鼠背部创面分别以康惠尔、美皮康、爱立敷敷料覆盖，间断缝合固定。在术后3d和7d每组随机选5只进行创面愈合图像采集分析．并从病理学角度定量观察分析创面上皮化和肉芽组织生长的情况。结果爱立敷敷料组小鼠术后3d和7d的平均创面愈合率为31．79％和78．45％，高于另外两组，差异有统计学意义（P〈0．05）；组织病理学分析发现术后7d爱立敷敷料组小鼠创面组织的新生上皮长度较另外两组更长，同时爱立敷敷料组的创面肉芽组织厚度较美皮康敷料组更厚。结论对于小鼠全层缺损创面而言，爱立敷敷料可以显著促进创面的肉芽组织生长和再上皮化，进而促进创面愈合。Objective To evaluate the efficacy and feasibility of three kinds of foam dressings in the wound healing.Methods Totally 30 BALB/C mice were divided into three groups, and 1 × 1 cm full-thickness defects on the back of mice were prepared. The wounds were covered with Comfeel dressing, Mepilex dressing and Allevyn dressing, and then the wounds were sutured and fixed. Five mice were selected in each group randomly at day 3 and day 7 after surgery, then the results were analyzed with Image-pro plus 6.0 software. Situation of epithelization and granulation tissue were analyzed by quantitative observation analysis from the perspective of pathology.Results Wound healing rate of Allevyn dressing group at day 3 and day 7 after surgery were 31.79% and 78.45%, which were higher than the data of the other two groups （P〈0. 05 ）. Pathological analysis found that, in the Allevyn dressing group at 7 d after surgery, the length of new epithelium of the wound tissue was longer than the other two groups; at the same time, the wound granulation tissue of the Allevyn dressing group was thicker than that of the Mepilex dressing group.Conclusions Among the three kinds of foam dressings, Allevyn dressing can significantly promote the granulation tissue growth of wound and epithelization, and then promote the wound healing.

关 键 词：皮肤护理 泡沫敷料 创面愈合 肉芽组织 

分 类 号：R47[医药卫生—护理学]