白附子不同炮制品药理作用评价研究  

Pharmacological Effects of Different Prepared Typhonii Rhizoma

作　　者：熊成成 蔡婉萍 林嘉娜 陈文政[1] 聂容珍 李书渊[1] 陈艳芬[1] 

机构地区：[1]广东药科大学中药学院,广东广州510006

出　　处：《中药材》2016年第8期1763-1766,共4页Journal of Chinese Medicinal Materials

基　　金：广东药学院2015年省级大学生创新创业训练计划项目(201510573034)

摘　　要：目的:综合评价白附子生品及不同炮制品的作用差别。方法:采用小鼠自主活动试验、睡眠试验、回苏灵惊厥试验考察白附子不同炮制品的镇静和抗惊厥作用;以醋酸扭体法、甲醛致痛法、二甲苯耳肿胀法来考察其抗炎镇痛作用;应用主成分分析法对白附子不同炮制品的药理作用进行综合分析。结果:白附子能明显减少小鼠自发活动,延长惊厥潜伏期,减少扭体次数、舔足时间和耳肿胀度;主成分分析结果表明,各样品综合作用顺序从强到弱依次为白附子姜矾制品、矾制品、生品、姜制品。结论:白附子生品及炮制品具有不同程度的镇静、抗惊厥及抗炎、镇痛作用。Objective： To evaluate the different actions of crude and prepared Typhonii Rhizoma through pharmacological and statistical methods. Methods： Spontaneous activity test,sleep test,and seizure induced by dimefline in mice were used to examine the sedative and anticonvulsant effects of different prepared products of Typhonii Rhizoma. Twisting induced by acetic acid,law pain induced by formaldehyde,and ear swelling caused by xylene were applied to examine the anti-inflammatory and analgesic effects of those different prepared products. Then the pharmacological effects of different prepared Typhonii Rhizoma were comprehensively analyzed by principal components analysis method. Results： Typhonii Rhizoma significantly reduced the spontaneous activities of mice,prolonged the convulsions latency,decreased twisting times,licking time and ear swelling. The principal components analysis results showed that the sample order from strong to weak was Typhonii Rhizoma prepared by ginger and alum,prepared by alum,crude Typhonii Rhizoma,and those prepared by ginger. Conclusion： Crude and prepared Typhonii Rhizoma exert sedative,anticonvulsant,analgesic and anti-inflammatory effects in different degrees.

关 键 词：白附子 炮制 药理作用 主成分分析法 

分 类 号：R283.1[医药卫生—中药学] R285.5[医药卫生—中医学]