活性氧在中性粒细胞胞外诱捕网形成中的作用  

The role of reactive oxygen species in the formation of neutrophil extracellular traps

作　　者：徐佳丽[1] 高飞[1] 刘彦虹[1] 

机构地区：[1]哈尔滨医科大学附属第二医院检验科,150086

出　　处：《国际免疫学杂志》2016年第6期574-578,共5页International Journal of Immunology

基　　金：国家自然科学基金（81541031）

摘　　要：中性粒细胞胞外诱捕网（NETs）是胞外的一种DNA网状结构,其可网罗、杀伤病原体从而参与机体固有免疫应答.然而在某些情况下NETs会引发一系列自身免疫性疾病.研究表明,在NETs形成过程中活性氧（ROS）起到至关重要的作用.阐述活性氧与NETs形成的相互作用,进一步讨论了尚未完全明确的活性氧与NETs的关系,包括还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶产生的ROS的作用,依赖NADPH氧化酶产生NETs的分子机制,以及非NADPH氧化酶产生的ROS的作用,从多方面分析ROS与NETs形成的关系.Neutrophil Extracellular Traps （NETs） are reticulate structures of extracellular DNA,the snare,kill pathogens and thus involved in the body＇s innate immune defense.However NETs can also cause a range of autoimmune diseases in some cases.Studies have shown that reactive oxygen species （ROS） play a crucial role in the formation course of NETs.The review analyzes the evidence to date on the interplay between ROS and NETosis,and discusses several further aspects of the ROS-NET relationship that are incompletely understood.These aspects include the role of NADPH oxidase-derived ROS,the molecular requirements of NADPH oxidase-dependent NETosis and ROS from sources other than NADPH oxidase.We conclude that ROS interact with NETosis in a multidimensional manner.

关 键 词：中性粒细胞 中性粒细胞胞外诱捕网 活性氧 NADPH氧化酶 MAPK/ERK 

分 类 号：R698.2[医药卫生—泌尿科学]