Facile Synthesis of Unsymmetrical N-Aryl-2,2-di(1H-indol-3-yl) Acetamide Derivatives  

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作  者:ZHOU Yan LI Renjun WANG Xiaolong HE Ling GUAN Mei WU Yong 

机构地区:[1]Key Laboratory of Drug Targeting and Drug Delivery System of Education Ministry,West China School of Pharmacy, Siehuan University, Chengdu 610041, P. R. China [2]Department of Medicinal Chemistry and Key Laboratory of Drug Targeting of Education Ministry of China, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China [3]West China Hospital, Siehuan University, Chengdu 610041, P. R. China

出  处:《Chemical Research in Chinese Universities》2016年第6期959-966,共8页高等学校化学研究(英文版)

摘  要:A facile and highly efficient method has been developed for the synthesis of unsymmetrical N-aryl-2,2-di(1H-indol-3-yl)acetamide derivatives by regioselective Friedel-Crafts alkylation of the N-aryl-2-hydroxy-2-(1H-indol-3-yl) acetamide derivatives with various indoles catalyzed by 2 mol/L H2SO4 at room temperature in ashort reaction time, the yield was up to 94%.

关 键 词:N-Aryl-2 2-di(1H-mdol-3-yl)acetamide derivative Indole Unsymmetry FRIEDEL-CRAFTS alkylation Bronsted acid 

分 类 号:O[理学]

 

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