隔物温和灸对膝骨关节炎患者血清IL-1及TNF-?含量的影响  

The Effect of Indirect Gentle Moxibustion on Serum IL-1 and TNF-a Contents in Patients with Knee Osteoarthritis

作　　者：李秀彬 李正祥 王立新 

机构地区：[1]浙江省温岭市中医院,温岭317500

出　　处：《上海针灸杂志》2016年第12期1459-1461,共3页Shanghai Journal of Acupuncture and Moxibustion

基　　金：温岭市科技项目(2014C31BC0011)

摘　　要：目的观察隔物温和灸对膝骨关节炎患者血清IL-1及TNF-?含量的影响,初步探讨其作用机理。方法根据病情采用随机对照研究方案,以针刺疗法为基础疗法,治疗组采用隔物温和灸,对照组采用物理热疗加拔罐疗法,对患者治疗前后血清IL-1及TNF-?含量及WOMAC骨关节炎指数进行分析比较。结果两组患者治疗前后血清IL-1及TNF-?含量及WOMAC骨关节炎指数方面比较差异有统计学意义(P<0.05),治疗组治疗后血清IL-1及TNF-?含量及WOMAC骨关节炎指数方面优于对照组(P<0.05)。结论隔物温和灸能有效降低膝骨关节炎患者血清IL-1及TNF-?含量,为其减少炎症刺激等作用机制提供了一定的分子细胞生物学及生物组织工程学方面的依据。Objective To investigate the effect of indirect gentle moxibustion on serum IL-1 and TNF-αcontents in patients with knee osteoarthritis and explore the mechanism of its action. Method A randomized controlled trial was conducted according to the patient＇s condition. Besides acupuncture as basic treatment, the treatment group received indirect gentle moxibustion and the control group, thermotherapy plus cupping. Pre-treatment and post-treatment serum IL-1 and TNF-αcontents and the Western Ontario and McMaster Universities Osteoarthritis Index （WOMAC） scores were analyzed in the patients and compared between the two groups. Result There were statistically significant pre-/post-treatment differences in serum IL-1 and TNF-α contents and the Western Ontario and McMaster Universities Osteoarthritis Index （WOMAC） score in the two groups （P〈0.05）. After treatment, serum IL-1 and TNF-αcontents and the Western Ontario and McMaster Universities Osteoarthritis Index （WOMAC） score were lower in the treatment group than in the control group. Conclusion Indirect gentle moxibustion can effectively decrease serum IL-1 and TNF-αcontents in patients with knee osteoarthritis. That provides a certain molecular cytobiological and bio tissue engineering basis for the mechanism of its action in reducing inflammatory stimulation.

关 键 词：针刺 骨关节炎 膝关节 白细胞介素1 肿瘤坏死因子 艾条灸 药饼灸疗法 电针 

分 类 号：R246.2[医药卫生—针灸推拿学]