低分子肝素治疗重症急性胰腺炎的临床效果分析及机制研究  

Clinical analysis of low molecular weight heparin on the efficacy of severe acute pancreatitis

作　　者：吴同飞[1] 朱功兵[1] 张杨[1] 肖开提.依不拉音 

机构地区：[1]新疆医科大学第一附属医院急救中心外科,新疆乌鲁木齐830054

出　　处：《中国现代普通外科进展》2016年第10期777-779,共3页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:探讨低分子肝素(LMWH)对重症急性胰腺炎(SAP)的临床疗效及可能机制。方法:采用前瞻性研究,将126例SAP患者分为普通治疗组(A组)和普通治疗+LMWH治疗组(B组),治疗2周后对比两组患者血清NO浓度、APACHⅡ评分、临床症状改善程度、胰腺Balthazar CT分级。结果:与A组相比,治疗2周后B组血清NO浓度显著升高(P<0.01)、APACHⅡ评分显著降低(P<0.01),临床症状显著改善(P<0.01),胰腺Balthazar CT分级显著降低(P<0.01)。结论:LMWH可能通过增加NO合成,利用其扩血管作用增加胰腺血流量,改善胰腺微循环障碍,发挥辅助性治疗作用,改善SAP转归。Objective： To investigate the clinical efficacy of low molecular weight heparin （LMWH） in the treatment of acute severe pancreatitis（SAP） and possible mechanisms. Methods： A prospective analysis of 126 cases of severe SAP patients,they were divided into conventional therapy group（groupA, n=61） and and conventional therapy group plus low molecular weight heparin therapy group（group B, n=65）, Comparative analysis of treatment the two groups of serum NO concentration, APACH Ⅱ score, clinical symptom improvement, Pancreatic Balthazar CT grading. Re. suits： Compared with group A, B group NO levels was significantly increased （P〈0.01）,APACH II score was significantly Iower（P〈0.05）, clinical symptoms improved significantly（P〈0.01 ）, Pancreatic Balthazar CT grading significantly reduced （P〈0.01）. Conclusion： LMWH possible by increasing serum NO concentration, leading to pancreatic tissue blood vessels to dilate, thereby improve pancreatic microcirculation.

关 键 词：重症急性胰腺炎 低分子肝素 一氧化氮 

分 类 号：R657.51[医药卫生—外科学]