慢性阻塞性肺疾病肺通气功能与CT肺气肿指数的研究  

Research on pulmonary ventilation function of COPD and CT index of pulmonary emphysema

作　　者：高永炳[1] 龚波[1] 武洪林[1] 周燕娟[1] 夏锡仪[1] 朱燕[1] 李尊[1] 许建兴[1] 郑建刚[1] 恽健 何赟 李红尧[1] 吴惠明[1] 王德杭[2] 

机构地区：[1]江苏大学附属武进医院影像科,江苏常州213002 [2]南京医科大学第一附属医院影像科,江苏南京210029

出　　处：《医学影像学杂志》2016年第12期2224-2227,共4页Journal of Medical Imaging

基　　金：江苏省第四期333高层次人才培养项目〔苏人才(2011)15号〕;江苏省常州市重点医学创新人才培养项目〔常卫科教〔2010)368号〕;江苏大学医学临床科技发展基金项目(编号:JLY20120044);江苏省常州市武进区科技计划项目(编号:WS201115)

摘　　要：通过双源CT与肺功能检查(PFT)数据对照分析,探讨CT肺气肿指数对慢性阻塞性肺疾病(COPD)患者肺功能评价的应用价值。方法收集108例COPD患者为研究对象,31例为对照组。进行PFT检查,根据结果将COPD患者严重程度分组,同时进行双源CT肺部扫描,运用肺功能分析软件测定肺气肿指数(LAV%,即肺低衰减区占肺总容积的百分比),分析LAV%与PFT的相关性。结果 COPD患者的LAV%>对照组(P<0.05),COPD患者不同严重程度组别LAV%差异有统计学意义(P<0.05)。结论 LAV%对于评价COPD患者的肺功能有重要意义,患者LAV%与COPD严重程度呈正相关。To explore the value of CT pulmonary emphysema index in assessing the pulmonary function in patients with chronic obstructive pulmonary disease （COPD） through the comparative analysis of data from dual-source CT and pulmonary function testing. Methods 108 patients who were diagnosed as having COPD were enrolled in the study, with 31 normal volunteers as control group. All of them underwent pulmonary function testing, all patients with COPD were grouped in terms of the severity of disease, and lung scanning by dual-source CT simultaneously. The lung emphysema index （ LAV%, the percentage of total lung area occupied by low attenuation area） was measured by pulmo analysis software, the correlation between LAV% and PF＇F was analyzed. Results The LAV% of patients with COPD was higher than that of control group （ P 〈 0.05 ）, there was significant difference on the LAV% among different severity groups （ P 〈0. 05）. Conclusion It is of great significance for using LAV% to evaluate the pulmonary function of patients with COPD, there is a positive correlation between the LAV% of patients and the severity of COPD.

关 键 词：慢性阻塞性肺疾病 体层摄影术 X线计算机 肺气肿指数 肺功能 

分 类 号：R563.3[医药卫生—呼吸系统] R814.42[医药卫生—内科学]