新疆伊犁州HIV感染者早期抗病毒治疗效果评价  

Effectiveness of early antiretroviral therapy among HIV-infected patients in Yili Prefecture of Xinjiang

作　　者：倪明健[1] 曾长玉 陈学玲[1] 胡晓远[1] 马媛媛[1] 张静[2] NI Ming-jian ZENG Chang-yu CHEN Xue-ling HU Xiao-yuan MA Yuan-yuan ZHANG Jing(Center for AIDS and STD Control and Prevention,Xinjiang Center for Disease Control and Prevention,Urumqi Xinjiang, 830011, China School of Public Health, X injiang Medical University, Urumqi X injiang, 830054, China)

机构地区：[1]新疆维吾尔自治区疾病预防控制中心性病艾滋病预防控制中心,新疆乌鲁木齐830011 [2]新疆医科大学公共卫生学院,新疆乌鲁木齐830054

出　　处：《职业与健康》2016年第21期2966-2969,共4页Occupation and Health

基　　金：国家"十二五"科技重大专项(2013ZX10004907)

摘　　要：目的了解新疆伊犁州人类免疫缺陷病毒(HIV)感染者早期高效抗逆转录病毒治疗后效果及相关影响因素。方法收集淋巴细胞计数>350个/μl研究对象的基线情况及治疗后各随访时点相关资料并进行统计分析。结果共收集651例HIV感染者信息,基线CD_4^+T淋巴细胞计数为(489.0±138.0)个/μl;治疗后3、6、9、12、18、24、30个月CD_4^+T淋巴细胞计数与基线相比分别上升了59.8、89.0、104.9、100.9、109.9、112.7和120.9个/μl,差异有统计学意义(P<0.05);免疫应答成功率为58.0%,临床分期为Ⅰ或Ⅱ期(OR=0.359,95%CI:0.138~0.934)、未合并丙型肝炎(OR=0.530,95%CI:0.304~0.925)、基线CD_4^+T淋巴细胞计数350~500个/μl(OR=0.559,95%CI:0.387~0.826)、未因依从性差曾停止治疗(OR=0.531,95%CI:0.319~0.883)的研究对象病毒抑制率要高于相应的对照组,差异有统计学意义(P<0.05);病毒抑制率为78.8%,分析发现各组间差异无统计学意义(P>0.05)。结论新疆伊犁州HIV感染者在早期启动抗病毒治疗后取得了较好的效果。[Objective]To analyze the effectiveness and related factors of early antiretroviral therapy among HIV-infected patients in Yili Prefecture of Xinjiang.[Methods]The objects were HIV-infected patients with CD4^＋T lymphocyte counts 350 cells/μl received therapy for the first time in Yili Prefecture,and their baseline and follow-up data were analyzed.[Results]Totally 651 cases were collected,and baseline CD4^＋T lymphocyte counts was（489.0±138.0）cells/μl. In the 3,6,9,12,18,24 and 30 months after treatment,the CD4^＋T lymphocyte counts respectively increased by 59.8,89.0,104.9,100.9,109.9,112.7 and 120.9 cells/μl as compared with the baseline date,and the difference was statistically significant（P〈0.05）. The rate of immune response was 58.0%.The people who was in Ⅰor Ⅱstage（OR=0.359,95% CI：0.138-0.934）,not infected with hepatitis C（OR=0.530,95% CI：0.304-0.925）,baseline CD4^＋T lymphocyte counts was 350-500 cells/μl（OR =0.559,95% CI：0.387-0.826）,and had not stopped treatment for difficult compliance（OR=0.531,95% CI：0.319-0.883）had higher virus inhibition rate than the control group,and the difference was statistically significant（P〈0.05）. The rate of virological suppression was 78.8%,there was no statistically significant difference among groups（P〈0.05）.[Conclusion]In Xinjiang,the HIV-infected patients have a better effect after early antiretroviral therapy.

关 键 词：人类免疫缺陷病毒感染者 免疫应答 病毒抑制 

分 类 号：R181.3[医药卫生—流行病学]