奥替溴铵治疗糖尿病腹泻的临床疗效及其对肠道菌群的影响  

The clinical efficacy and the effect of otilonium bromide on intestinal flora in patients with diabetic diarrhea

作　　者：徐灵芝[1] 何斐[1] 泮瑛瑛 张伟[1] 应巧[1] 

机构地区：[1]浙江省台州市立医院内分泌科,浙江台州318000

出　　处：《中国中西医结合消化杂志》2016年第11期868-870,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：[目的]探讨奥替溴铵治疗糖尿病腹泻的临床疗效,以及对肠道菌群的影响。[方法]2015年2月~2016年2月,我院80例糖尿病腹泻患者,根据随机数字法,将其分为对照组（易蒙停）和观察组（奥替溴铵）,每组各40例,比较2组治疗的临床疗效、治疗前后空腹血糖及餐后2h血糖水平变化情况,以及治疗前后肠道菌群变化情况。[结果]观察组治疗的总有效率较对照组明显增高,P〈0.05;观察组治疗后餐后2h血糖水平较对照组明显降低,P〈0.05;观察组治疗后双歧杆菌、拟杆菌等厌氧菌数量较对照组明显增高,而肠杆菌、肠球菌、酵母菌等需氧菌数量较对照组明显降低,P〈0.05。[结论]奥替溴铵能够有效调节糖尿病腹泻患者的肠道菌群失调,显著改善患者的临床症状及体征。[Objective]To study the clinical efficacy and the effect of otilonium bromide on intestinal flora in patients with diabetic diarrhea.[Methods]The 80 patients with diabetic diarrhea in our hospital during the period from Feb 2015 to Feb 2016 were randomized into the control group（imodium）and the observation group（otilonium bromide）according to random number method,40 patients per group.The clinical efficacy of treatment,blood sugar level changes of fasting and postprandial 2hon pre-and post-treatment,and the changes of intestinal flora on pre-and post-treatment in two groups were compared.[Results]Compared with the control group,the total effective rate of treatment was significantly increased in the observation group（P〈0.05）.Blood sugar level on postprandial 2hwas obviously decreased on post-treatment in the observation group（P〈0.05）.Compared with the control group,the number of anaerobic bacteria such as bifidobacterium species and bacteroides was significantly increased and the number of aerobic bacteria such as bacillus,Escherichia coli and yeast was obviously decreased on post-treatment in the observation group（P〈0.05）.[Conclusion]The treatment of otilonium bromide can effectively regulate the intestinal flora imbalance in patients with diabetic diarrhea and significantly improve the patients＇clinical symptoms and signs.

关 键 词：奥替溴铵 糖尿病腹泻 肠道菌群 

分 类 号：R442.2[医药卫生—诊断学]