介孔二氧化硅纳米粒对穿心莲内酯载药性能及药物释放的影响  

Effects of mesoporous silica nanoparticles on the drug loading and release of andrographolide

作　　者：吕洁琼[1] 林君红[1] 崔升淼[1] LYU Jieqiong LIN Junhong CUI Shengmiao(School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China)

机构地区：[1]广东药科大学中药学院,广东广州510006

出　　处：《广东药学院学报》2016年第5期555-558,共4页Academic Journal of Guangdong College of Pharmacy

基　　金：国家自然科学基金青年基金项目(81302715);2015年广东省大学生创新创业训练计划项目(201510573033)

摘　　要：目的制备介孔二氧化硅纳米粒,并研究它对穿心莲内酯载药性能及药物释放的影响。方法以介孔二氧化硅纳米粒负载穿心莲内酯,采用N2吸附、DSC、SEM、XRPD进行表征,并测定纳米粒的载药量和体外药物释放量。结果投药量为10%、20%、25%、30%时,药物质量分数分别为6.89%、14.8%、19.6%、22.3%;载药后样品分散均匀,外观、大小与载药前相比均无显著变化;载药后比表面积、孔容量、孔径均比载药前降低。体外溶出度试验表明,穿心莲内酯介孔二氧化硅纳米粒(MSNs-AND)的体外溶出度均比穿心莲内酯原料药高,且差异具有统计学意义。结论介孔二氧化硅纳米粒可实现穿心莲内酯的高负载,并可显著提高其溶出度。Objective To prepare mesoporous silica nanoparticles and study their effects on Andrographolide（ AND） drug loading and release. Methods The mesoporous silica nanoparticles loaded with AND were prepared. Nitrogen adsorption,DSC,SEM and XRPD were used for characterization. The drug loadings and the cumulative release percentage of MSNs-AND were determined. Results The content of the dosage of10%,20%,25% and 30% were 6.89%,14.8%,19.6% and 22.3%. After loaded,the dispersion of MSNsAND was more uniform,but there were no significant changes in their appearance and size. But after loaded,the specific surface area,pore volume and pore size were reduced. The dissolution of the MSNsAND was higher than AND crude drug and the difference was significant. Conclusion The mesoporous silica nanoparticles can help to achieve a high drug loading of AND,and increase its dissolution rate significantly.

关 键 词：穿心莲内酯 介孔二氧化硅 纳米粒 体外释放 

分 类 号：R284[医药卫生—中药学]