242例矮身材儿童病因及IGF-I、骨龄分析  

Analysis of etiology,IGF-Ⅰ and bone age of 242 children with short stature

作　　者：苑晓超 李志红[2] 马文彬[2] 周雪[2] 杨茜[2] 尹飞[2] 

机构地区：[1]承德医学院,河北承德067000 [2]保定市第一中心医院内分泌二科,河北保定071000

出　　处：《中国妇幼健康研究》2016年第11期1296-1298,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨儿童矮身材的病因分类及胰岛素样生长因子-Ⅰ(IGF-Ⅰ)水平和骨龄落后情况。方法回顾性分析2015年至2016年在保定市第一中心医院内分泌科就诊的242例矮身材儿童的临床资料。结果在242例患儿中,特发性矮身材(ISS)占25.62%,家族性矮身材占16.94%,生长激素缺乏性矮身材(GHD)占14.88%、营养缺乏性矮身材(ND)占13.22%,宫内发育迟缓(IUGR)占7.85%,以上均为导致矮身材的前5位疾病或原因,而在7岁以下矮身材儿童中,ND占第1位。GHD、ND、IUGR 3组相比,IGF-Ⅰ、△年龄(实际年龄-骨龄)有统计学差异(F值分别为42.317和14.346,均P<0.01)。GHD组、ND组分别与IUGR组比较,IGF-Ⅰ、△年龄均有统计学差异(IGF-Ⅰ:t值分别为8.732和7.443,均P<0.01。△年龄:t值分别为5.431和2.496,均P<0.05)。而GHD组、ND组两组间比较,△年龄有统计学差异(t=3.051,P<0.05),IGF-Ⅰ比较无统计学差异(P>0.05)。结论 ISS及GHD为导致儿童矮身材的主要病因,可根据患儿IGF-I及骨龄初步判断矮身材的病因,ND为7岁以下矮身材儿童的重要病因。Objective To explore the etiology , insulin-like growth-factor-Ⅰ （ IGF-Ⅰ） and bone age of the children with short stature . Methods Retrospective study was conducted on clinical data of 242 children with short stature visiting department of endocrinology in First Center Hospital in Baoding between 2015 and 2016.Results In 242 patients, idiopathic short stature （ISS） occupied 25.62%, familial short stature occupied 16.94%, growth hormone deficiency （ GHD） short stature occupied 14.88%, nutritional deficiency （ ND） growth retardation occupied 13.22% and intrauterine growth retardation （IUGR） occupied 7.85%, respectively.They were the top five short statures .But ND growth retardation was the first cause in children with short stature under 7 years old .Statistical differences were found in IGF-Ⅰand △age （actual age-bone age） among GHD group, ND group and IUGR group （F value was 42.317 and 14.346,respectively, both P〈0.01）.GHD group and ND group were statistically different from IUGR group in IGF-Ⅰand△age （IGF-Ⅰ：t value was 8.732 and 7.443,respectively, both P〈0.01;△age：t value was 5.431 and 2.496,respectively, both P〈0.05）.Compared to ND group,△age was significantly different （t=3.051,P〈0.05） but IGF-Ⅰwas not in GHD group.Conclusion ISS and GHD are the main causes of children with short stature .Etiology of short stature can be initially judged according to IGF-Ⅰ and bone age .ND growth retardation accounts an important position in the etiology of children under the age of 7.

关 键 词：矮身材 病因 胰岛素样生长因子-Ⅰ 骨龄 

分 类 号：R729[医药卫生—儿科]