兰州城区孕妇甲状腺功能现况调查  

Investigation on current situation of thyroid function of pregnant women in Lanzhou City

作　　者：吴岐珍[1] 王文玲[1] 李海鸿[1] 唐中锋 许晓英[1] 张丽莉[1] 周敏[1] 

机构地区：[1]甘肃省妇幼保健院围产医学中心,甘肃兰州730050

出　　处：《中国妇幼健康研究》2016年第11期1328-1331,共4页Chinese Journal of Woman and Child Health Research

基　　金：甘肃省科技支撑计划-社会发展类资助项目(目编号:144FKCA068)

摘　　要：目的了解兰州城区孕妇甲状腺功能的现状及其影响因素。方法随机选择2014年6月至2016年2月自愿在甘肃省妇幼保健院进行围产保健,并长期居住在兰州市城区的不同孕期孕妇1 127例,测定其空腹静脉血甲状腺功能,包括促甲状腺激素(TSH)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPOAb)水平及空腹尿碘值。分析甲状腺功能与孕妇年龄、孕周及孕前体质量指数的关系,以及尿碘值与甲状腺功能是否存在联系,各项甲状腺功能指标之间是否存在联系。结果不同年龄孕妇的TSH值之间比较有统计学差异(F=3.202,P=0.007),FT4值之间比较有统计学差异(F=2.508,P=0.029),TPOAb值之间比较无统计学差异(H=2.268,P=0.811)。不同孕期孕妇的TSH值之间比较有统计学差异(F=4.173,P=0.016),FT4值之间比较有统计学差异(F=20.290,P=0.000),TPOAb值之间比较无统计学差异(H=0.136,P=0.934)。不同孕前体重指数孕妇的TSH值之间比较没有统计学差异(F=0.936,P=0.423),FT4值之间比较无统计学差异(F=2.309,P=0.075),TPOAb值之间比较有统计学差异(H=12.333,P=0.006)。尿碘值与TSH值负相关(r=-0.070,P=0.016);尿碘值与FT4值正相关(r=0.187,P=0.000);尿碘值与TPOAb值负相关(r=-0.066,P=0.020)。TSH值与TPOAb值之间正相关(r=0.073,P=0.014),FT4值与TPOAb值之间无相关性(r=-0.016,P=0.597)。结论兰州城区孕妇的甲状腺功能与妊娠年龄、孕期、孕前体重指数、碘营养状况之间存在联系。应当加强这一地区孕妇尿碘及甲状腺功能指标的监测,为提高人口质量提拱了新的思路。Objective To understand current situation of thyroid function of pregnant women in Lanzhou urban area and its influence factors.Methods Altogether 1 127 cases of pregnant women in various gestational age living in Lanzhou urban district were randomly selected, all of whom received perinatal service in Maternal and Child Health Care Hospital of Gansu Province from June 2014 to February 2016 .Fasting venous thyroid function including thyroid stimulating hormone （ TSH） , free thyroxine （ FT4 ） , thyroid peroxidase antibody （ TPOAb） and fasting urine iodine were measured .Analysis was carried out on relation between thyroid function and maternal age , gestational week and prepregnant body mass index （ BMI ） , and whether there was relation between urinary iodine value and thyroid function and links among different thyroid function indexes were also studied .Results For pregnant women with different age , difference in TSH values （F=3.202, P=0.007） and FT4 values （F=2.508, P=0.029） had statistical significance, while difference in TPOAb values was not significant （H=2.268, P=0.811）.For pregnant women in different pregnancy age , difference in TSH values （F=4.173, P=0.016） and FT4 values （F =20.290, P=0.000） had statistical significance, while difference in TPOAb values had no statistically significance （H=0.136, P=0.934）.For pregnant women with different prepregnant BMI , difference in TSH values （F=0.936, P=0.423） and FT4 values （F=2.309, P =0.075） had no statistical significance, while TPOAb values were significantly different （H=12.333, P=0.006）.Urinary iodine value was negatively related to TSH value （r=-0.070, P=0.016） and TPOAb value （r=-0.066, P=0.020）, while it was positively related to FT4 value （r=0.187, P=0.000）, TSH value was positively related to TPOAb value （r=0.073, P=0.014）, but FT4 value was not related to TPOAb value （r=-0.016, P=0.597）.Conclusion Thyroid function of pregnant women is associated with age , gestational age , prepr

关 键 词：甲状腺功能 孕妇 碘营养状况 年龄 体质量指数 兰州城区 

分 类 号：R714.1[医药卫生—妇产科学]