曲美他嗪对心脏X综合征合并2型糖尿病患者冠状动脉慢血流的影响  

Effects of trimetazidine on coronary slow flow in cardiac syndrome X complicated with type 2 diabetes

作　　者：李法权[1] 钟一鸣[1] 曾山[1] 王小萍[1] 刘心强[1] 钟华平[1] LI Faquan ZHONG Yiming ZENG Shan WANG Xiaoping LIU Xinqiang ZHONG Huaping(Department of Cardiology, the First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, 341000,China)

机构地区：[1]赣南医学院第一附属医院心内一科,江西赣州341000

出　　处：《临床心血管病杂志》2016年第12期1215-1217,共3页Journal of Clinical Cardiology

摘　　要：目的:研究曲美他嗪对心脏X综合征合并2型糖尿病患者冠状动脉慢血流的治疗作用。方法:将87例心脏X综合征合并2型糖尿病冠状动脉造影时出现慢血流的患者随机分为曲美他嗪组(45例)和对照组(42例)。对照组采用拜阿司匹林100mg/d、单硝酸异山梨酯20mg/d、阿托伐他汀20mg/d联合严格控制血糖治疗,曲美他嗪组在此基础上加用曲美他嗪20mg/次,3次/d,连续治疗6个月。观察治疗前后两组患者冠状动脉TIMI血流分级和冠状动脉血流储备的变化。结果:6个月治疗结束后,曲美他嗪及对照组冠状动脉血流储备值较治疗前均有明显提高(P<0.05),且曲美他嗪组提高幅度显著高于对照组(P<0.05)。曲美他嗪组冠状动脉TIMI血流改善的有效率也显著高于对照组(P<0.05)。结论:长期曲美他嗪治疗可改善心脏X综合征合并糖尿病及冠状动脉慢血流患者的TIMI血流分级和冠状动脉血流储备功能。Objective：To investigate the therapeutic effect of trimetazidine on coronary slow flow in cardiac syndrome X patients who complicating type 2diabetes.Method：The 87 cases with coronary slow flow complicated with cardiac syndrome X and type 2diabetes were randomly divided into trimetazidine group（45cases）and control group（42cases）.Patients in control group were treated with aspirin（100mg/d）,isosorbide mononitrate（20mg/d）and atorvastatin（20mg/d）,whereas patients in trimetazidine group received trimetazidine（20 mg,3times/day）in addition to the therapeutic regimen of control group.The changes of TIMI grade of coronary artery blood flow and coronary flow reserve（CFR）before and after 6months of treatment in the two groups were measured.Result：After 6 months of treatment,the CFR values in both groups were significantly elevated compared with baseline value（P〈0.05）.In addition,the CFR value in trimetazidine group was higher than that in control group.The improvement rate of TIMI grade of coronary artery blood flow in trimetazidine group was significantly higher than that in control group（P〈0.05）.Conclusion：Long-term administration of trimetazidine in the cardiac syndrome X patients who complating type 2diabetes and coronary slow flow may improve the TIMI grade of coronary artery blood flow and coronary flow reserve functon.

关 键 词：冠心病 冠状动脉慢血流 曲美他嗪 冠状动脉血流储备 

分 类 号：R541.4[医药卫生—心血管疾病]