老年H型高血压患者血浆致动脉硬化指数与颈动脉内膜中层厚度的相关性研究  

The correlation between plasma arteriosclerosis index and carotid intimamedia thickness in elderly patients with H-type hypertension

作　　者：黄勇先 李旭东 郭俊瑾 季竹君 龚明华 HUANG Yongxian LI Xudong GUO Junjin JI Zhujun GONG Minghua(Department of Cardiology, Xishan People＇s Hospital, Wuxi, Jiangsu, 214011, China)

机构地区：[1]无锡市锡山人民医院心内科,江苏无锡214011

出　　处：《临床心血管病杂志》2016年第12期1229-1231,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨H型高血压患者血同型半胱氨酸(HCY)水平及血浆致动脉硬化指数(AIP)与颈动脉硬化的相关性。方法:所有入选的高血压患者(排除继发性高血压),均测量血压、身高、体重、HCY、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。计算出AIP及体质指数(BMI)。超声检测颈动脉内膜-中层厚度(IMT),并计算斑块积分。根据血浆HCY水平将患者分为H型高血压组(HCY≥10μmol/L)和非H型高血压组(HCY<10μmol/L),比较两组AIP、血脂、IMT及斑块积分差异。采用Pearson和Logistic检验进行相关性分析。结果:H型高血压组血HCY水平、AIP、LDL-C、颈动脉IMT及斑块积分均高于对照组(均P<0.05)。Logistic多因素回归分析显示,HCY、AIP、LDL-C是颈动脉内膜增厚的危险因素。结论:老年H型高血压血HCY及AIP与IMT密切相关,且为正相关。HCY、AIP、LDL-C是颈动脉内膜增厚的危险因素,HCY及AIP可作为动脉硬化早期预测因子。Objective：To investigate the correlation between blood homocysteine（HCY）level and plasma atherosclerosis index（AIP）and carotid atherosclerosis in patients with type H hypertension.Method：The blood pressure,height,weight,HCY,triglyceride（TG）,total cholesterol（TC）,high density lipoprotein cholesterol（HDL-C）and low-density lipoprotein cholesterol（LDL-C）were measured in all selected hypertensive patients（excluding secondary hypertension）.The plasma AIP and body mass index（BMI）were calculated.Carotid intima-media thickness（IMT）was measured by ultrasonography and the plaque score was calculated.According to the plasma HCY levels,cases were divided into H hypertension group（HCY≥10μmol/L,H group）and non H hypertension group（HCY10μmol/L,control group）,the AIP,blood lipid,IMT and plaque score were compared between the two groups.Pearson and Logistic test were used to analyse the relationship.Result：The levels of plasma HCY,AIP,LDL-C,carotid IMT and plaque score in H group were significantly higher than those in control group（all P〈0.05）.Further logistic regression analysis showed that HCY,AIP and LDL-C were risk factors for carotid intima thickening.Conclusion：The levels of blood HCY and AIP are closely positively related to carotid IMT in elderly patients with H-type hypertension.HCY,AIP and LDL-C are risk factors of carotid IMT,HCY and AIP could be used as early predictors of atherosclerosis.

关 键 词：高血压 同型半胱氨酸 血浆致动脉硬化指数 颈动脉内膜中层厚度 动脉硬化 

分 类 号：R446.1[医药卫生—诊断学]