云南地区慢性心力衰竭患者血尿酸变化特点  

Features of serum uric acid in patients with chronic heart failure in Yunnan

作　　者：赵鑫 陈章荣 吴新华 杨云贵 董瑜 杨瑛 刘宏 张健[3] ZHAO Xin CHEN Zhangrong WU Xinhua YANG Yungui DONG Yu YANG Ying LIU Hong ZHANG Jian(Department of Cardiology, The Affiliated Hospital of Dali University, Dali, Yunnan, 671000, China Cadre Infirmary, Qujing City People＇s Hospital Heart Failure Center, Cardiovascular Institute and Fuwai Hospital,CAMS and PUMS)

机构地区：[1]大理大学附属医院心内科,云南大理671000 [2]曲靖市第一人民医院干疗科 [3]北京协和医学大学中国医学科学院阜外心血管病医院心力衰竭中心

出　　处：《临床心血管病杂志》2016年第12期1232-1234,共3页Journal of Clinical Cardiology

基　　金："十二五"国家科技支撑计划重大项目心力衰竭项目(No:2011BA111B02);国家自然科学基金(No:81560073)

摘　　要：目的:研究慢性心力衰竭(CHF)与血尿酸(SUA)的关系,为云南地区CHF患者的防治提供新的科学依据。方法:回顾性研究CHF患者共计2 483例,分析其SUA水平与心功能级别、性别、年龄、B型脑钠肽(BNP)、左室射血分数(LVEF)、左室舒张末期内径(LVEDd)的关系。结果:CHF患者SUA增高,且SUA增高与心功能级别有关。高尿酸血症(HUA)患者SUA水平与心功能分级有关(P<0.05),而SUA正常的患者其SUA水平与心功能级别无关。男性SUA水平明显高于女性。青年组SUA水平最高。SUA水平与心功能、LVEDd和BNP呈正相关,与LVEF呈负相关。结论:CHF患者的SUA水平与性别、年龄、心功能分级、BNP、LVEF、LVEDd相关,SUA可能是预测CHF预后的独立危险因素之一。Objective：To explore the relationship between serum uric acid（SUA）and chronic heart failure（CHF）in Yunnan Province.Method：The clinical data of 2483 patients with CHF were collected and the patients who missed serum uric acid（SUA）were excluded.The relationship between SUA level and cardiac function grade,gender,age,type B brain natriuretic peptide（BNP）,left ventricular ejection fraction（LVEF）,left ventricular end diastolic diameter（LVEDd）was investigated.Result：SUA levels of HUA group were increased with cardiac function deterioration（P〈0.05）.The SUA level of the male was significantly higher than that in the female.The young men had higher SUA levels.SUA level was positively correlated with cardiac function,LVEDd and BNP,while negatively correlated with LVEF.Conclusion：The SUA level in patients with CHF are high in Yunnan Province,HUA could be an independent risk factor of CHF.

关 键 词：血尿酸 心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]