ADAM17在膜蛋白胞外结构域剪切机制中的作用  

Role of ADAM17 in Transmembrane Protein Shedding

作　　者：王超男[1] 董洁[1] 邵宁生[1] WANG Chaonan DONG Jie SHAO Ningsheng(Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing, 100850, China)

机构地区：[1]军事医学科学院基础医学研究所,北京市100850

出　　处：《医学分子生物学杂志》2016年第6期345-349,共5页Journal of Medical Molecular Biology

基　　金：国家自然科学基金（No.81572846）

摘　　要：ADAM17蛋白属于解聚素金属蛋白酶家族，是Ⅰ型多结构域跨膜蛋白，表达于多种组织及肿瘤细胞中。该蛋白是剪切跨膜蛋白胞外结构域的关键蛋白，对膜结合型蛋白的翻译后修饰及蛋白活性的产生具有重要的调节作用，与免疫反应、肿瘤的发生发展、神经发育、病毒传播及衰老等过程密切相关。对ADAM17跨膜蛋白胞外段的剪切功能及其生物学意义进行深入研究，对相关疾病的诊断与治疗具有重要的理论与临床应用价值。ADAM17, a member of a disintegrin and metalloprotease family, is a typeⅠmul-tidomain transmembrane protein and it is found to express in a variety of tissues and cancer cells. ADAM17 is the key protein in shedding of transmembrane ectodomain, and plays an important regulatory role in the post-translation modification and protein activities, and it has been shown to be related with immune responses, tumor progression, neural development, viral transmission and aging progression. Here, we review the advances in the ectodomain-shedding function of ADAM17 and the related biological significances.

关 键 词：ADAM17蛋白 跨膜蛋白 胞外剪切 翻译后修饰 

分 类 号：Q71[生物学—分子生物学]