CSE／H2 S在心血管系统的作用及机制  

Protective Role of CSE/H2 S in Cardiovascular System and Its Mecha-nism

作　　者：肖淼淼[1] 郑康超 肖辉雪[3] 杨向俐 施维[1] 田磊[1] 吕家高[1] XIAO Miaomiao ZHENG Kangchao XIAO Huixue YANG Xiangli SHI Wei TIAN Lei LV Jiagao(Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China Guangzhou Medical University, Guangzhou, 510089, China Shunde Polytechnic, Foshan, Guangdong, 528300, China)

机构地区：[1] 华中科技大学附属同济医院心内科,武汉市430030 [2] 广州医科大学,广州市510089 [3] 顺德职业技术学院,广东省佛山市528300

出　　处：《医学分子生物学杂志》2016年第6期365-370,共6页Journal of Medical Molecular Biology

摘　　要：硫化氢（ H2 S）是一种内源性气体信号分子，在机体各系统中均发挥着重要作用。体内H2 S的主要由多种酶催化生成，其在心血管系统主要由胱硫醚-γ-裂解酶（ cystathionine-r-lyase， CSE）催化产生。近年来研究显示CSE／H2 S通路与多种心血管疾病的发生发展关系密切。文章以CSE／H2 S通路在心血管系统的作用为切入点，阐述H2 S在心血管系统的保护作用及其分子调控机制。Hydrogen sulfide （ H2 S） is an important endogenous gaseous signaling molecule in multiple organ systems. The production of endogenous H2 S is regulated by a variety of enzymes. Cystathionine-γ-lyase （ CSE） is the main H2 S-generating enzyme in the cardiovascular system. Re-cent studies have shown that the pathway of CSE/H2 S is closely related to the development of most cardiovascular diseases. Here, we review the protective effect of H2 S in the cardiovascular system and the molecular regulatory mechanism of CSE/H2 S pathway in the cardiovascular system.

关 键 词：硫化氢 心血管 分子机制 

分 类 号：R34[医药卫生—基础医学]