玉泉丸联合盐酸贝那普利对2型糖尿病肾病患者保护作用的机制研究  

The Mechanism Study of Protective Effect of Yuquan Pills on Type 2 Diabetic Kidney Disease

作　　者：彭聪[1] 高明松[1] 孔彩霞[1] 谢海鹰[1] 龚艳琳[1] 段苗[1] 李伟[1] 

机构地区：[1]武汉市中西医结合医院,湖北武汉430022

出　　处：《湖北中医药大学学报》2016年第6期40-42,共3页Journal of Hubei University of Chinese Medicine

基　　金：武汉市卫生计生科研基金(项目编号:武卫生计生【2015】6号WZ15A03)

摘　　要：目的观察玉泉丸联合盐酸贝那普利对2型糖尿病肾病患者的保护作用及其机制。方法将80例2型糖尿病肾病患者随机分为两组。对照组予以胰岛素及口服降糖药治疗,有合并症者配合相关药物对症治疗,同时口服盐酸贝那普利片。治疗组在基础治疗同时口服玉泉丸方水煎剂。两组均治疗2个月,观察两组治疗前后尿微量白蛋白(m A1b)、尿白蛋白排泄率(UAER)、糖化血红蛋白(Hb A1c)、一氧化氮(NO)、内皮素(ET)、肿瘤坏死因子-α(TNF-α)和白细胞介素-1(IL-1)等的变化。结果治疗组m A1b、UAER、ET、TNF-α、IL-1明显下降,NO明显升高,与对照组比较有显著性差异(P<0.05)。结论玉泉丸对DKD患者具有保护作用,其机制可能与保护内皮细胞功能、减轻炎症反应有关。Objective To investigate the protective effect and the mechanism of Yuquan pills on type 2 diabetic kidney disease（DKD）. Methods 80 cases of DKD patients were randomly divided into control group（n =40）and treatment group（n =32）. Control group was treated by Yuquan pills and Insulin pills, patients with complications were treated with related drugs, and orally took Benazepril Hydrochloride tablets. Treatment group took Yuquan pills decoction on the basis of routine treatment. Both groups were treated for 2 months. Urine microalhumin （ reA1b） , urine albumin excretion rate （ UAER ） , glycosylated hemoglobin A1c （ HbA1c） , nitrogen monoxidum （ NO ） , endothelin （ ET ） , tumor necrosis factor alpha（ TNF - α）, interleukin - 1 （ IL - 1 ） were assessed before and after treatment. Results After treatment, mA1b, UAER, ET levels of both groups decreased and ET levels increased evidently compared with before treatment（ P 〈 0. 05 ） , there was a significant defference between the two groups（ P 〈 0. 05 ）. Conclusion Yuqnan pills can decrease inflammatory cytokines and protect endothelial cell,it has a protective effect of kidney function in DKD.

关 键 词：2型糖尿病 糖尿病肾病 中西医结合疗法 盐酸贝那普利 

分 类 号：R259[医药卫生—中西医结合]