结核感染的固有免疫识别  

Innate Immune Recognition of Mycobacterium Tuberculosis

作　　者：刘金彪[1] 徐瑶[2] 高建峰[1] 周立[1] LIU Jinbiao XU Yao GAO Jianfeng ZHOU Li(Animal Bio-Safety Level Ⅲ Laboratory at the Center for Animal Experiment, Wuhan University, Wuhan 430071, Hubei, China Institute of Biological and Medicine, Wuhan University of Science and Technology, Wuhan 430081, Hubei, China)

机构地区：[1]武汉大学动物实验中心/ABSL-Ⅲ实验室,湖北武汉30071 [2]武汉科技大学生物医学研究院,湖北武汉430081

出　　处：《武汉大学学报（理学版）》2016年第6期495-501,共7页Journal of Wuhan University:Natural Science Edition

基　　金：国家自然科学基金(81201261;81301428和81571962);湖北省自然科学基金(2015CFB164);中国博士后科学基金(2013M531745和2015M572199);中央高校基本科研业务费专项(2042015kf0188和2042015kf0017)资助项目

摘　　要：肺结核是结核分支杆菌(Mycobacterium tuberculosis,MTB)感染引起的重大传染病.固有免疫细胞如巨噬细胞、树突状细胞和自然杀伤细胞等在宿主抵抗MTB入侵过程中发挥了重要作用,多种模式识别受体参与了MTB的识别.本文从固有免疫细胞及其免疫识别受体两个方面综述了结核感染的识别过程,着重探讨了Toll样受体、C型凝集素受体和NOD样受体在MTB识别中的作用机制.Tuberculosis（TB）,caused by Mycobacterium tuberculosis（MTB）,is still a global public health problem.Innate immunity plays an important role in the host defense against MTB,and the first step in this process is the recognition of MTB by cells of the innate immune system,such as macrophages,dendritic cells and natural killer（NK）cells.Several classes of pattern recognition receptors（PRRs）are involved in the recognition of MTB.We summarized the cells of innate immune and PRRs involved in MTB recognition,and concentrated on the recognized mechanism of PRRs,such as Toll-like receptors,C-type lectin receptors,and Nod-like receptors.

关 键 词：结核分枝杆菌 模式识别受体 免疫识别 固有免疫 

分 类 号：R378[医药卫生—病原生物学]