重度子痫前期病人血清FABP4的表达及意义  

THE EXPRESSION OF ADIPOCYTE FATTY ACID-BINDING PROTEIN AND ITS SIGNIFICANCE IN SEREVE PREECLAMPSIA PATIENTS

作　　者：杨秀凤[1] 位菊峰[1] 张文华[1] 

机构地区：[1]青岛大学医学院第二附属医院妇产科,山东青岛266042

出　　处：《青岛大学医学院学报》2016年第5期595-597,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨血清脂肪型脂肪酸结合蛋白（FABP4）在重度子痫前期（SPE）病人中的表达及意义。方法选择2013年12月—2014年12月在我科确诊为SPE的60例孕妇作为SPE组,选择同期于本院就诊的60例健康孕妇作为对照组。采用酶联免疫吸附试验（ELISA）法及全自动生化仪检测孕妇和脐血血清FABP4、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白（HDL）及低密度脂蛋白（LDL）水平。对两组上述指标进行比较,并分析SPE组孕妇血清FABP4水平与平均动脉压（MAP）的相关性,以及孕妇和脐血血清FABP4水平与新生儿体质量的相关性。结果 SPE组孕妇血清FABP4、TC、TG及LDL水平较对照组升高,HDL水平较对照组降低,差异均有显著性（t=34.87-129.43,P〈0.05）。SPE组孕妇血清FABP4水平与MAP水平呈正相关（r=0.534,P〈0.05）,与新生儿体质量呈负相关（r=-0.477,P〈0.05）;SPE组脐血FABP4水平与新生儿体质量呈正相关（r=0.393,P〈0.05）。结论血清FABP4水平升高和血脂代谢紊乱可能与SPE发病有关,影响胎儿生长。Objective To explore the expression of adipocyte fatty acid-binding protein（FABP4）and its significance in severe preeclampsia（SPE）patients. Methods Sixty pregnant women diagnosed with SPE-in our department during October2013-December 2014-were selected as SPE group,and 60 healthy pregnant women visited our department in the same period as control group.The serum and umbilical cord blood levels of FABP4,triglyceride（TG）,total cholesterol（TC）,low density lipoprotein（LDL）and high density lipoprotein（HDL）were detected using enzymelinked immunosorbent assay（ELISA）and full automatic biochemical analyzer.The above markers were compared between the two groups,the correlation between serum FABP4 of pregnant women and mean arterial pressure（MAP）in SPE group,as well as the correlation between the level of FABP4 in patient＇s serum and umbilical cord blood and birth weight were analyzed. Results The serum levels of FABP4,TC,TG and LDL in SPE group were significantly higher than that in the control group,while that of HDL was significantly lower（t=34.87-129.43,P〈0.05）.In SPE group,the serum level of FABP4 was positively correlated with MAP（r=0.534,P〈0.05）,while that of FABP4 was negatively correlated with neonatal body mass（r=-0.477,P〈0.05）,and the level of FABP4 in umbilical cord blood was positively correlated with neonatal body mass（r=0.393,P〈0.05）. Conclusion Elevation of serum FABP4 level and metabolic disorder of serum lipids may be related to the pathogenesis of severe preeclampsia and affecting fetal growth.

关 键 词：先兆子痫 脂肪酸结合蛋白质类 血脂异常 

分 类 号：R714.244[医药卫生—妇产科学]