通过溶解度法研究纤维素类聚合物抑制超饱和非洛地平结晶的特征  

Investigation on inhibition of cellulose polymers against supersaturated felodipine crystallization by solubility method

作　　者：时念秋[1,2] 张勇[2] 冯波[1] 张秀荣[1] 李正强[2] 齐宪荣[3] 

机构地区：[1]吉林医药学院,吉林吉林132013 [2]吉林大学生命科学学院,吉林长春130012 [3]北京大学药学院,北京100191

出　　处：《中国医院药学杂志》2016年第24期2152-2156,共5页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金(编号:81602654);吉林省科技发展计划资助项目(编号:20160520046JH和20140311110YY);吉林省教育厅资助项目(编号:吉教科合字2015第401号);吉林市杰出青年科技人才项目(编号:201464053);中国博士后科学基金面上项目(编号:2015M571374)

摘　　要：目的:研究不同纤维素类聚合物抑制超饱和状态下非洛地平结晶的特征。方法:通过制备超饱和状态下的无定型非洛地平,并采用测定溶解度的方法,来分析纤维素聚合物类型、加入量、离子强度和黏度对于BCS II类模型药物非洛地平的结晶抑制影响。结果:HPMC E15具有最强的结晶抑制效应,纤维素聚合物加入量增多、纤维素聚合物黏度的减少和离子强度的增大会导致聚合物抑制非洛地平结晶能力的增强。结论:本研究有助于阐明纤维素类聚合物抑制超饱和状态下药物结晶的规律,HPMC E15对抑制非洛地平结晶具有显著作用和应用潜力。OBJECTIVE To investigate inhibition of cellulose polymers against supersaturated felodipine crystallization.METHODS The research was performed by preparing supersaturated amorphous felodipine solid,and was carried out by measuring the solubility of felodipine.The types,added amounts,ionic intensity and viscosity of cellulose polymers were employed to assess the crystallization inhibition effect of polymers against the BCS II class drug felodipine.RESULTS HPMC E15 suggested the strongest crystallization inhibition effect.The enhancement of crystallization inhibition was observed for more polymers added,decrease of viscosity and increase of ionic intensity.CONCLUSION Cellulose polymers inhibit crystallization of supersaturated drugs.HPMC E15 has significant effect and application potential for inhibiting crystallization of felodipine.

关 键 词：纤维素类聚合物 非洛地平 溶解度 超饱和状态 结晶抑制 

分 类 号：R944[医药卫生—药剂学]