乌药总生物碱抗炎镇痛药理学研究  

Pharmacology research on anti-inflammatory and analgesic effects of total alkaloids from Linderae Radix

作　　者：张剑[1,2] 罗人仕[1,2] 杨瑜[2,3] 刘冰晶[1,2] 

机构地区：[1]赣南医学院药学院,江西赣州341000 [2]江西省脑血管药理重点实验室,江西赣州341000 [3]赣南医学院第三附属医院,江西赣州341000

出　　处：《中国医院药学杂志》2016年第24期2187-2190,共4页Chinese Journal of Hospital Pharmacy

基　　金：江西省教育厅科技重点项目(编号:GJJ10698);江西省教育厅科技项目(编号:GJJ11565);江西省卫生厅中医药科研计划(编号:2011A153)

摘　　要：目的:对乌药总生物碱抗炎镇痛作用进行研究。方法:采用p-二甲苯致小鼠耳廓肿胀法和角叉菜胶致后足跖肿胀法、小鼠热扳法和乙酸致小鼠扭体法等方法来评估用索氏法氨水-氯仿提取得到的乌药总生物碱的抗炎镇痛效果。结果:乌药总生物碱有缓解p-二甲苯致小鼠耳廓肿胀及角叉菜胶致后足跖肿胀效果,能减少小鼠在热板上舔后足的次数和减少乙酸致小鼠扭体的次数,镇痛效果显著。结论:乌药总生物碱抗炎镇痛作用明显。OBJECTIVE To study anti-inflammatory and analgesic effects of total alkaloids from Linderae Radix.METHODS The anti-inflammatory and analgesic effects of total alkaloids extracted fromLinderae Radixby Soxhlet method with the ammonia and chloroform as the solvents,were observed by p-xylene-induced mouse ear swelling method,carrageenan-induced paw swelling method,hot plate method and acetic acid writhing method in mice.RESULTS Total alkaloids fromLinderae Radixcould obviously relieve mice ear swelling and carrageenan-induced paw swelling,significantly reduce the hind licking times and decrease acid-induced mouse writhing times.The analgesic effect of Linderae Radix was exact.CONCLUSION Linderae Radixhas obvious analgesic and anti-inflammatory effects in mice.

关 键 词：乌药 总生物碱 抗炎 镇痛 

分 类 号：R969[医药卫生—药理学]