MR钆对比剂全身性不良反应的研究:18540例连续病例分析  

A registry study of non-renal adverse reactions to Gadolinium-based contrast media:analysis of 18540 consecutive cases

作　　者：孙艳[1] 郭小超[1] 黄勇[1] 张宏[1] 罗健[1] 王霄英[1] 

机构地区：[1]北京大学第一医院医学影像科,北京100034

出　　处：《放射学实践》2016年第12期1159-1162,共4页Radiologic Practice

摘　　要：目的:探讨静脉注射钆对比剂的全身性不良反应发生情况。方法:利用对比剂安全信息系统的数据,搜集行MR增强检查的18540例连续患者的病例资料,对注射钆对比剂后的全身性反应进行统计,分析不良事件出现时间及其与对比剂的相关性,分为急性不良反应(<1h)、迟发性不良反应(1h^1w)和晚迟发不良反应(>1w)三类,进一步将不良反应分为轻、中、重度三类,分别进行统计分析。结果:18540例共发生全身性不良反应24例,总发生率为0.13%。急性不良反应16例(0.09%),其中轻度9例、中度4例、重度3例。迟发性不良反应8例(0.04%),其中轻度6例、中度2例。无晚迟发不良反应。结论:MR增强检查注射钆对比剂发生全身性不良反应的概率很低,但有发生急性重度不良反应的可能,应予以关注。Objective：To investigate the incidence of non-renal adverse reactions of Gadolinium based contrast media. Methods：A cohort of 18540 patients who were examined with contrast enhanced MRI was included in this study. The clinical data of all patients were derived from the Contrast Media Safety Information System （CMSIS） and were retrospectively studied. The non-renal adverse reactions were recorded and classified according to onset time after contrast medium injection （acute reaction, 〈 1 hour ; late reaction, 1 hour to 1 week; very late reaction, 〉 1 week） and severity （mild, moderate, severe）. Results：Totally 24 cases （0.13%,24/18540） with non-renal adverse reaction were recorded,including sixteen cases （0. 09%, 16/18540） with acute adverse reaction of different severity （9 mild, 4 moderate, and 3 severe）, eight cases （0.04% ,8/18540） with late adverse reaction of different severity （6 mild,2 moderate）. No case with very late adverse reac- tion was reported. Conclusion：The risk of adverse reaction to Gadolinium based contrast medium is fairly low, but severe reactions may oecur which should be paid attention to.

关 键 词：磁共振成像 钆 对比剂 不良反应 

分 类 号：R445.2[医药卫生—影像医学与核医学] R981.1[医药卫生—诊断学]