压缩倾角薄层光学层析成像系统  

Laminar optical tomography system with condensed dip-angle

作　　者：赵会娟[1,2] 贾梦宇[1] 秦转萍[3,4] 王爽[1] 陈雪影[1] 李娇[1,2] 张林[1] 高峰[1,2] 

机构地区：[1]天津大学精密仪器与光电子工程学院,天津300072 [2]天津市生物医学检测技术与仪器重点实验室,天津300072 [3]天津市信息传感与智能控制重点实验室,天津300222 [4]天津职业技术师范大学自动化与电气工程学院,天津300222

出　　处：《红外与毫米波学报》2016年第6期688-693,共6页Journal of Infrared and Millimeter Waves

基　　金：国家自然科学基金(81271618;81371602;61475115;61475116;81401453;61575140;81571723);天津市自然科学基金(13JCZDJC28000;14JCQNJC14400;15JCZDJC31800;15JCQNJC14500);天津职业技术师范大学校科研发展基金(KYQD14007)~~

摘　　要：首先研究了LOT中光线倾斜角度对光在组织体内分布的影响,在此基础上设计并完成了压缩倾角薄层光学层析成像(cdaLOT)系统,提出了矫正扫描振镜枕型畸变的新方法,并发展了基于虚拟源-扩散近似技术和GPU的LOT快速图像重建算法.光路模拟结果表明,cdaLOT系统可使入射主光线倾角减小为传统LOT系统的1/2.cdaLOT系统将测量值与蒙特卡洛模拟结果的相对误差由传统系统的38%降低为18%,从而缓解了实际测量方式和正向数学模型的不匹配性.仿体成像实验表明:重建异质体的吸收系数、位置和形状与真实情况基本相符.The influence of the dip angle on light distribution inside tissue was investigated. Based on the investigation, a LOT system with condensed dip-angle （cdaLOT） over the whole detection range was developed. A new method for correcting the deflection-angle of galvanometer mirrors was also proposed. A fast image reconstruction algorithm for LOT was also developed based on the virtual- source diffusion approximation and GPU. Light path simulation showed that the developed cdaLOT system decreased the dip angle of the incident light to 1/2 of that of the traditional LOT system. The relative deviation of the measured data to MC results was about 18 % for cdaLOT while that for tradi- tional LOT was as large as 38%. Reconstructed images showed that the reconstructed absorption coeffi- cient, and the position and shape of the inhomogeneity coincided with the real target.

关 键 词：薄层光学层析成像 倾角 图像重建 测量系统 

分 类 号：Q63[生物学—生物物理学]