中医药治疗2型糖尿病合并抑郁的系统评价  

Chinese medicine treatment of type 2 diabetes and depression evaluation system

作　　者：尚成英 常柏[2] 温莹莹[1] 何霞霞 SHANG Cheng-ying CHANG Bai WEN Ying-yingl HE Xia-xia(Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China Metabolic Diseases Hospital, Tianjin Medical University, Tianjin 300070, China)

机构地区：[1]天津中医药大学,天津300193 [2]天津医科大学代谢病医院,天津300070

出　　处：《天津中医药大学学报》2016年第6期376-379,共4页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81273914)

摘　　要：[目的]系统评价中医药治疗2型糖尿病合并抑郁的临床疗效与安全性。[方法]计算机检索维普数据库、中国知网、万方数据库、中国生物医学文献数据库、Pubmed、Cochrace Library,纳入中医药治疗2型糖尿病合并抑郁的随机对照试验,检索时限均从建库至2015年12月,对纳入研究的资料进行评价,用Rev Man 5.3软件进行分析。[结果]共纳入符合要求的9篇文献,合计593例患者。Meta分析结果显示,与对照组相比,中医药治疗2型糖尿病合并抑郁在总有效率、用药后汉密尔顿(HAMD)评分变化:糖化血红蛋白(Hb A1c)变化水平:不良反应方面具有一定的优势,差异均有统计学意义。[结论]现有研究文献表明试验组对2型糖尿病合并抑郁在总有效率、HAMD、Hb A1c变化方面优于对照组,同时在不良反应发生率方面,低于对照组。[Objective] To evaluate the safety and efficacy of the traditional Chinese medicine on depression in patients with type 2 diabetes mellitus. [Methods] All randomized controlled trials （RCTs） or quasi-randomized controlled trials from the database established to December 2015, It was searched on the VIP,CNKI, Wan fang, CBM, Pubmed,the Cochrane Liabrary about the traditional Chinese medicine on depression in patients with type 2 diabetes mellitus. And then Revman 5.3 was performed for meta-analyses. [Results] Nine trials including 593 cases were identified. Meta-analysis showed that： Compared with control group, the effective rate in The experimental group was higher than control group. Hamilton （HAMD） score changes： glycated hemoglobin （HbAlc） levels： adverse events were superior than normal group, the differences were statistieally signifieant. [Conclusion] The existing research literature suggests that The effects of the traditional Chinese medicine on depression in patients with type 2 diabetes mellitus are better than Western medicine group,especially in the total efficiency, HAMD, HbAlc,and no severe adverse event was reported.

关 键 词：中医药 2型糖尿病 抑郁 临床疗效 系统评价 

分 类 号：R587.1[医药卫生—内分泌]