T淋巴细胞在哮喘发病机制中的作用  

Development and study of T cells in the pathogenesis of asthma

作　　者：赵春兰[1] 于华凤[2] 吕欣[2] 

机构地区：[1]泰山医学院研究生部,泰安271000 [2]山东大学齐鲁儿童医院,济南250022

出　　处：《生命的化学》2016年第6期868-873,共6页Chemistry of Life

基　　金：山东省自然科学基金(ZR2010HM127)

摘　　要：支气管哮喘(简称哮喘)的本质是慢性气道炎症,是多种炎症细胞(如嗜酸性粒细胞、肥大细胞、T淋巴细胞、中性粒细胞等)和其介质共同参与引起的慢性炎症反应,而T淋巴细胞在其中发挥重要作用。T淋巴细胞目前主要分为四个亚群,分别是Th1、Th2、Th17和Treg亚群。过去曾认为Th1/Th2平衡失调是哮喘发病的关键因素,但近年研究发现Th17/Treg及Th2/Treg的平衡失调在哮喘的发病机制中同样发挥巨大作用,且日益受到重视。本文就T细胞在哮喘发病机制中的作用及研究进展做一综述。Bronchial asthma （asthma）, the basic nature of which is chronic airway inflammation, is the pro- cess of chronic inflammation reaction induced together by a variety of inflammatory cells （eosinophils, mast cells, T lymphocytes, neutrophils, etc.） and the media of them, and T lymphocytes play an important role in the process. Nowadays T lymphocytes are mainly divided into four subgroups, respectively Th1, Th2, Thl7, Treg subsets. The imbalance of Th 1/Th2 was always thought to be a key factor in the pathogenesis of asthma, but recently it has been found that the disorder of Th17/Treg has a tremendous importance, which has been paid more and more attention. Besides the imbalance of Th2/Treg also has an important significance. There is a complex relationship between them. This review summarizes the recent advance about development and study of T cells in the pathogenesis of asthma.

关 键 词：TH1细胞 TH2细胞 TH17细胞 TREG细胞 哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]