高莴苣化学成分研究  

Chemical constituents of Lactuca elata

作　　者：殷田田 白意晓[2] 庄方方[1] 曹轲[1] 闫福林[1] YIN Tian-tian BAI Yi-xiao ZHUANG Fang-fang CAO Ke YAN Fu-lin(School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, Henan Province, China Drug and Equipment Sec- tion, Langzhong People＇s Hospital, Langzhong 637400, Sichuan Province, China)

机构地区：[1]新乡医学院药学院,河南新乡453003 [2]阆中市人民医院药械科,四川阆中637400

出　　处：《新乡医学院学报》2016年第2期91-95,共5页Journal of Xinxiang Medical University

基　　金：国家自然科学基金资助项目(编号:81172953)

摘　　要：目的研究高莴苣根茎的化学成分。方法用柱色谱等方法对其化学成分进行分离纯化,通过核磁共振等现代波谱方法确定化合物结构。结果从高莴苣中共分离得到8个化合物,分别鉴定为:熊果烷-12-烯-11-羰基-3-醇正二十八酸酯(1),木栓酮(2),豆甾醇(3),β-谷甾醇(4),β-胡萝卜苷(5),(2S,3S,4R,10E)-2-[(2R)-2-hydroxytetracosano-ylamino]-10-octadecene-1,3,4-triol(6),Aralia cerebroside(7),2,6-二氧甲基-1,4-苯醌(8)。结论在分离得到的这8个化合物中,化合物1、2、3、7、8为首次从该植物中分离得到,为进一步研究其生物活性奠定了基础。Objective To investigate the chemical compositions of Lactuca elata. Methods The chemical constituents were separated by silica gel column chromatography and their structures were determined by spectroscopic experiments such asnuclear magnetic resonance. Results As a result,eight compounds were isolated and identified as ursa-12-ene-11-one-3-ol octocosate（ 1）,3-oxo-friedlane（ 2）,stigmasterol（ 3）,β-stitosterol（ 4）,β-daucosterol（ 5）,（ 2S,3S,4R,10E）-2-[（ 2R）-2-hydroxytetracosano-ylamino]-10-octadecene-1,3,4-triol（ 6）,Aralia cerebroside（ 7） and 2,6-dimethoxy-1,4-benzoquinone（ 8）. Conclusion In the eight compounds,compounds 1,2,3,7,8 are separated from this plant for the first time.

关 键 词：菊科 高莴苣 化学成分 

分 类 号：R284.1[医药卫生—中药学]