丹参酮ⅡA磺酸钠注射液治疗糖尿病足疗效观察  

Effect of sodium tanshinone ⅡA sulfonate injection on diabetic foot

作　　者：张永文[1] 张洁[1] 吴秉司[1] 张晓立[1] 梅海云[1] ZHANG Yong-wen ZHANG Jie WU Bing-si ZHANG Xiao-li MEI Hai-yun(Department of Endocrinology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine , Nanjing 210014 , Jiangsu Province, China)

机构地区：[1]南京中医药大学附属南京市中西医结合医院内分泌科,江苏南京210014

出　　处：《新乡医学院学报》2016年第2期142-144,147,共4页Journal of Xinxiang Medical University

摘　　要：目的探讨丹参酮ⅡA磺酸钠注射液治疗糖尿病足(DF)的临床效果。方法选取2013年2月至2014年2月在南京市中西医结合医院住院治疗的DF患者50例,根据治疗方法分为观察组和对照组,每组25例。对照组患者给予常规治疗措施,观察组患者在常规治疗的基础上,加用丹参酮ⅡA磺酸钠注射液80 mg,静脉滴注,每日1次,治疗2周。比较治疗前后2组患者足部溃疡面积、外周血白细胞(WBC)计数、C反应蛋白(CRP)水平、疼痛强度(PPI)、疼痛分级指数(PRI)、疼痛视觉模拟评分法(VAS)评分及临床疗效。结果治疗前2组患者足部溃疡面积比较差异无统计学意义(P>0.05);治疗2周末,2组患者足部溃疡面积均显著小于治疗前(P<0.05);治疗1、2周末,观察组患者足部溃疡面积显著小于对照组(P<0.05)。治疗前2组患者WBC计数及CRP水平比较差异均无统计学意义(P>0.05),治疗1、2周末,2组患者WBC计数及CRP水平均显著低于治疗前(P<0.05);观察组患者WBC计数及CRP水平均显著低于对照组(P<0.05)。治疗前2组患者PRI、PPI、疼痛VAS评分比较差异均无统计学意义(P>0.05);治疗1、2周末,2组患者PRI、PPI、疼痛VAS评分均显著低于治疗前(P<0.05);观察组患者PRI、PPI、疼痛VAS评分均显著低于对照组(P<0.05)。观察组和对照组患者治疗总有效率分别为96.0%(24/25)和72.0%(18/25),观察组患者治疗总有效率高于对照组(P<0.05)。结论丹参酮ⅡA磺酸钠注射液治疗DF可以有效抑制炎症反应,促进溃疡愈合,减轻患者疼痛。Objective To explore the effect of sodium tanshinone ⅡA sulfonate injection on diabetic foot（ DF）. Methods Fifty patients with DF were selected in Nanjing Integrated Traditional Chinese and Western Medicine Hospital from February 2013 to February 2014. The patients were divided into observation group and control group according to therapeutic method,with twenty-five cases in each group. The patients in control group were treated with conventional therapy. Based on the conventional therapy,the patients in observation group were treated with sodium tanshinone ⅡA sulfonate injection 80 mg by intravenously guttae,once a day for two weeks. The ulcer area of foot,peripheral blood white blood cell（ WBC） count,C-reactive protein（ CRP） level,present pain intensity（ PPI）,pain rating index（ PRI）,visual analogue scales（ VAS） score of pain and clinical effect were compared between the two groups before and after treatment. Results There was no significant difference in the ulcer area of foot between the two groups before treatment（ P〉0. 05）. The ulcer area of foot at the end of two weeks treatment was significantly less than that before treatment in the two groups（ P〈0. 05）. The ulcer area of foot in observation group was significantly less than that in control group at the end of one week and two weeks treatment（ P〈0. 05）. There was no significant difference in WBC count and CRP level between the two groups before treatment（ P〉0. 05）. The WBC count and CRP level at the end of one week and two weeks treatment were significantly lower than those before treatment in the two groups（ P〈0. 05）. The WBC count and CRP level in observation group were significantly lower than those in control group at the end of one week and two weeks treatment（ P〈0. 05）. There was no significant difference in PRI,PPI and VAS score of pain between the two groups before treatment（ P〉0. 05）. The PRI,PPI and VAS score of pain at the end of one and two weeks treatment were significantly

关 键 词：丹参酮ⅡA磺酸钠注射液 糖尿病足 创面愈合 疼痛 视觉模拟评分法 

分 类 号：R587.2[医药卫生—内分泌]