抗菌药物的药动学和药效学参数在临床用药中的意义  

The Significance of Pharmacokinetics and Pharmacodynamic Parameters of Antimicrobial Agents in Clinical Drug Use

作　　者：张秀杰 

机构地区：[1]珲春市中医医院药剂科,吉林珲春133300

出　　处：《中国卫生标准管理》2016年第22期94-96,共3页China Health Standard Management

摘　　要：目的探讨抗菌药物的药动学和药效学参数在临床用药中的意义。方法对我院2013年2月-2015年5月收治的210例住院患者抗菌药物使用情况进行归纳分析。结果抗菌药物的药动学、药效学参数与浓度、时间密切相关。其中氨基苷类药物抗药性明显,长期服用容易增加耐药性。此外A1组、B1组、A2组、B2组有效率分别为70.0%（21/30）、70.0%（21/30）、96.7%（29/30）、96.7%（29/30）,观察组（A2组、B2组）总有效率高于对照组（P〈0.05）。结论抗菌药物的药动学和药效学参数可为临床用药提供参考,提高用药科学性。Objective To study significance of pharmacokinetics and pharmacodynamic parameters of antimicrobial agents in clinical drug use. Methods The use of antimicrobial agents in 210 hospitalized patients admitted to our hospital from February 2013 to May 2015 were analyzed. Results The pharmacokinetic and pharmacodynamic parameters were closely related to the concentration and time.The amino glycosides drug resistance was obvious,long-term use easy to increase drug resistance.In addition,group A1,group B1,group A2 and group B2 of effective ratewere 70.0%（21/30）,70.0%（21/30）,96.7%（29/30）,96.7%（29/30） respectively. The total effective rate of the observation group（A2 group,B2 group） was higher than that of the control group（P 0.05）. Conclusion Antibacterial drug pharmacokinetic and pharmacodynamic parameters can provide a reference for clinical use,improve scientific medication.

关 键 词：抗菌药物 药动学 药效学参数 

分 类 号：R96[医药卫生—药理学]