环丙沙星和司氟沙星体外诱导肺炎克雷伯菌产生耐药性的研究  

Research the Drug Resistance of Klebsiella Pneumoniae Induced by Ciprofloxacin and Sparfloxacin in Vitro

作　　者：王晓茹[1] 

机构地区：[1]内蒙古师范大学医院药房,内蒙古呼和浩特010022

出　　处：《中国卫生标准管理》2016年第23期97-98,共2页China Health Standard Management

摘　　要：目的 探讨采用环丙沙星与司氟沙星体外诱导肺炎克雷伯菌产生耐药性的效果。方法 选取2014年3月~2015年3月该院146例标本,根据诱导方法差异性分为A组与B组,两组各为73例。B组采用司氟沙星进行体外诱导,A组则采用环丙沙星进行体外诱导,体外诱导结束后,分析对比两组耐药性。结果 通过采用不同体外诱导方法,A组肺炎克雷伯菌耐药性较低,两组对比差异具有统计学意义（P〈0.05）。结论 采用环丙沙星体外诱导肺炎克雷伯菌,可降低耐药性,保障治疗疗效。Objective To study the drug resistance of klebsiella pneumoniae induced by ciprotloxacin and sparfloxacin m vitro. Methods 146 specimens collected from March 2014 to March 2015 in our hospital were selected. The subjects were divided into group A and group B according to the different induction methods, 73 cases in each group, group B took sparfloxacin, group A took ciprofloxacm. After the induction, the drug resistance was analyzed. Results The drug resistance of klebsiella pneumoniae for group A was significantly lower than that of group B （ P 〈 0.05 ） . Conclusion The induction of ciprofloxacin in vitro can reduce the drug resistance of klebsiella pneumoniae. It is of great importance in clinical practice.

关 键 词：环丙沙星 司氟沙星 体外诱导 肺炎克雷伯菌 耐药性 

分 类 号：R974[医药卫生—药品]