文拉法辛与氟西汀治疗抑郁症对照研究  

Controlled Study of Venlafaxine and Fluoxetine in Treatment of Depression

作　　者：林义川[1] 郑金炽[1] 赖晓茹 

机构地区：[1]福建省泉州市第三医院第四病区,福建泉州362000

出　　处：《中国卫生标准管理》2016年第23期107-110,共4页China Health Standard Management

摘　　要：目的评价文拉法辛与氟西汀治疗抑郁症患者的疗效及安全性。方法将100例抑郁症患者随机分为研究组和对照组,每组50例,研究组给予文拉法辛治疗,对照组给予氟西汀治疗。于治疗前及治疗1、2、4、6周末采用汉密尔顿抑郁量表(HAMD)及临床总体印象量表(CGI-SI)比较治疗效果,副作用量表(TESS)比较治疗过程副作用。结果文拉法辛组总体有效率为88%,氟西汀组总体有效率为90%,两组比较差异无统计学意义(P>0.05);两组患者使用文拉法辛和氟西汀治疗6周后CGI-SI评分与治疗前比较均下降(P<0.05),但两组患者组间比较差异无统计学意义(P>0.05);两组患者经过治疗HAMD评分与治疗前比较差异具有统计学意义(P<0.05),且文拉法辛组患者在第1和第2周末HAMD总分同氟西汀组比较差异具有统计学意义(P<0.05),而在第4、6周末两组患者HAMD总分的比较差异无统计学意义(P>0.05);两组患者在副作用方面经比较差异无统计学意义(P>0.05)。结论文拉法辛与氟西汀在治疗抑郁症患者总疗效差异无统计学意义,但文拉法辛能够更迅速改善抑郁症状,同时两者在副作用方面差异无统计学意义。Objective To evaluate the clinical efficacy and sat＇cry of venlafaxine and fluoxetine in the treatment of depression. Methods 100 patients with depression were selected and randomly divided into treatment group and the control group, 50 patients in each group. The treatment group was treated with venlafaxine and the control group was given fluoxetine. The hamilton rating scale （ HAMD ） and clinical global impression （ CGI-SI ） was adopted to evaluate the clinical efficacy, and the treatment emergent symptoms scale （ TESS ） was ~ldopted t＇or evaluating the security of the two groups before treatment, after treatment of first weekend, second weekend, forth weekend and sixth weekend. Results The total effective rate in venlafaxiue was 88%, and 90% in fluoxetine. The total effective rate after treatment had no statistical difference between the two groups （ P 〉 0.05 ） . The score of CGI-SI decreased in veolafaxine and fluoxetine group was statistically significant compared with before treatment （ P 〈 0.05）, but had no statistical difference between them （ P 〉 0.05 ） . The score of HAMD decreased in venlafaxine and fluoxetine group was statistically significant compared with before treamaent （ P 〈 0.05） . From the beginning of the first and second weenkend, the score of HAMD was significant diffeuent between the two groups （P 〈 0.05 ）, but had no statistical difference at the end of four, sixth weekend （P 〉 0.05 ） . There was no significant difference in adverse reactions between the two groups （ P 〉 0.05） . Conclusion There is no differences in clinical efficacy and adverse reactions between venlafaxine group and fluoxetine group, but the venlafaxine has a rapid onset.

关 键 词：文拉法辛 氟西汀 疗效 副作用 抑郁症 

分 类 号：R971[医药卫生—药品]