隐匿性乙型肝炎病毒感染的发生机制及检测方法进展  

Review of Occult Hepatitis B Virus Infection and the Detection Technology

作　　者：邵靓婧[1] 王长军[2] 

机构地区：[1]南京军区南京总医院血液病科,南京210002 [2]南京军区疾病预防控制中心,南京210002

出　　处：《医学综述》2016年第24期4902-4905,共4页Medical Recapitulate

基　　金：南京军区南京总医院院管课题(2013051)

摘　　要：乙型肝炎病毒(HBV)的高感染率,是隐匿性HBV感染(OBI)存在的基础。OBI是一种特殊形式的HBV感染,可通过输血、器官移植、血液透析等方式传播,其与慢性肝病、肝细胞癌及慢性丙型肝炎的发生、发展相关。OBI存在多种发生机制,随着研究技术的不断发展,OBI的检测方法也较为多样。建立操作简单、敏感、特异的HBV核酸检测方法,可以为实现OBI的快速筛查提供依据,以减少与它相关的潜在威胁。The high infection rate of hepatitis B virus（HBV） is the basis of the existence of occult hepatitis B virus infection （OBI）. OBI is a special form of HBV infection which can be spread through blood transfusion, organ transplantation, dialysis, etc. It is associated with the occurrence and development of chronic liver disease, chronic hepatitis C and hepatocellular carcinoma. Due to the varied pathogenesis mechanisms of OBI, with the development of research？ techniques,there are different kinds of detection methods for OBI. The establishment of simple, sensitive and specific HBV nucleic acid detection method can provide a basis for the rapid screening of OBI, to reduce the potential threats.

关 键 词：隐匿性乙型肝炎病毒感染 流行病学特点 发生机制 检测方法 

分 类 号：R373.2[医药卫生—病原生物学]