氯化琥珀胆碱对大鼠比目鱼肌离体单一肌梭传入放电的影响  

Effects of Suxamethonium Chloride on Afferent Discharges of Isolated Soleus Single Muscle Spindle in Rats

作　　者：余蕾[1] 樊小力[2] 赵雪红[3] 宋新爱[2] 

机构地区：[1]西安医学院,陕西西安710021 [2]西安交通大学,陕西西安710061 [3]湖北文理学院医学院,湖北襄阳441053

出　　处：《航天医学与医学工程》2016年第6期408-412,共5页Space Medicine & Medical Engineering

基　　金：国家自然科学基金青年基金项目(31300981)

摘　　要：目的探讨不同浓度氯化琥珀胆碱（suxamethonium chloride，Sch）对大鼠比目鱼肌离体单一肌梭传入放电的影响。方法采用空气隔绝法记录大鼠比目鱼肌离体单一肌梭传入放电，分别给予25mg／L、50mg／L、75ms／L、100mg／L、125mg／LSch灌流后，观察大鼠比目鱼肌离体单一肌梭传入放电的变化。结果1）给予25ms／LSch灌流后，大鼠比目鱼肌离体单一肌梭传入放电较灌流前无明显变化；2）分别给予50mg／L、75mg／LSch灌流后，肌梭传入放电较灌流前明显增多（p〈0．01）；3）给予100mg／LSch灌流后，肌梭传入放电较灌流前无明显变化；4）给予125ms／L Sch灌流后，肌梭传入放电较灌流前明显减少（P〈0．05）。结论一定浓度的氯化琥珀胆碱（50-75mg／L）可特异性地兴奋肌梭，使大鼠比目鱼肌离体单一肌梭传入放电明显增多；氯化琥珀胆碱浓度过高（≥125mg／L）反而会抑制大鼠比目鱼肌离体单一肌梭的传入放电。Objective To investigate the effects of suxamethonium chloride （Sch） with different concentrationson atterent discharges of isolated soleus single muscle spindle of rats. Methods The changes of Sch with differ-ent concentrations, which were 25 mg/L, 50 mg/L, 75 mg/L, I00 mg/L and 125 mg/L respectively, wereobserved, the air-gap technique was adopted to record the afferent activities of isolated soleus single musclespindle. Results 1 ） After administration of 25 mg/L Sch, the afferent discharges of isolated soleus single mus-cle spindle of rat were not significantly changed. 2） After administrations of 50 mg/L and 75 mg/L Sch, theafferent discharges of single 100 mg/L Sch, the afferent ministration of 125 mg/L Sc muscle spindle were signific discharges of single muscle h, the afferent discharges of antly increased（ P 〈 0.01 ）. 3 ） After administration of spindle were not significantly changed. 4） After ad- single muscle spindle were significantly reduced （ P 〈 0.05）. Conclusion Sch of certain concentration （50 -75 mg/L）specifically excites muscle spindle and obvi- ously increases the afferent discharges of isolated soleus single muscle spindle of rat. But Sch of high concen- tration （≥ 125 mg/L）inhibits the afferent discharges of isolated soleus single muscle spindle of rats.

关 键 词：氯化琥珀胆碱 比目鱼肌 肌梭 传入放电 大鼠 

分 类 号：Q445[生物学—生理学]