固本化痰法对支气管哮喘缓解期患者临床疗效及免疫功能的影响  

Influence of Clinical Efficacy and Immune Function of Patients with Bronchial Asthma at Remission Stage by the Method of Consolidating Origin and Resolving Phlegm

作　　者：石绍顺[1] 李丁蕾[1] 崔英海[1] 丁晓欢[1] 于国强[1] 姚明[1] 李明飞[1] 于雪峰[1] 李国信[1] 李中宇[1] 

机构地区：[1]辽宁中医药大学附属第二医院,辽宁沈阳110034

出　　处：《西部中医药》2016年第11期1-4,共4页Western Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药行业科研专项项目(编号200807034)

摘　　要：目的:探讨固本化痰法对支气管哮喘缓解期患者临床疗效及免疫功能的影响。方法:将支气管哮喘缓解期患者241例随机分为治疗组122例和对照组119例,对照组不予干预,治疗组口服金龙固本合剂,疗程120天,观察哮喘的复发率及患者血清免疫球蛋白(IgA、IgM、IgG、IgE)水平。结果:总有效率治疗组为96.46%,对照组为62.73%,2组比较差异有统计学意义(P<0.01);IgA:2组患者在治疗120天及随访360天时血清IgA比较差异均无统计学意义(P>0.05);治疗组在治疗120天及随访360天时血清IgA高于治疗前(P<0.01)。IgM:2组患者在随访360天时血清IgM比较差异均无统计学意义(P>0.05);治疗组在治疗120天时血清IgM高于对照组(P<0.05),对照组在120天时血清IgM与治疗前比较差异无统计学意义(P>0.05),而随访360天时高于治疗前(P<0.01)。IgG:2组患者在治疗120天时血清IgG比较无差异(P>0.05),随访360天时对照组血清IgG高于治疗组,其差异有统计学意义(P<0.01),2组治疗120天时血清IgG与治疗前比较均无差异(P>0.05)。IgE:2组患者在治疗120天时血清IgE比较无差异(P>0.05),随访360天时血清IgE治疗组低于对照组,其差异有统计学意义(P<0.01),治疗组在治疗120天及随访360天时血IgE与治疗前比较差异均有统计学意义(P<0.05)。结论:固本化痰法能明显减少支气管哮喘发作次数,具有调节免疫功能作用。Objective： To investigate the effect of the method of consolidating origin and resolving phlegm on the clinical effect and immune function of patients with bronchial asthma in remission stage. Methods： All 241 cases of bronchial asthma at remission stage were randomly divided into the treatment group with 122 cases and the control group with 119 cases. For a course of treatment for 120 days, the control group was not treated while the treatment group was treated with oral administration of JinLong GuBen mixture. The recurrence rate of the disease, serum immunoglobulin （IgA, IgM, IgG, IgE） levels and other indicators were observed. Results： The total effective rate of the treatment group was 96.46%, and the control group was 62.73%. The differences between the two groups was statistically significant （P〈0.01）; During the 360 days＇ follow-up, there was no difference in the blood IgA level between the two groups （P〉0.05） in the treatment of 120 days＇ and 360 days＇ follow-up. In the treatment group, the blood IgA was significantly higher than that before treatment （P〈0.05） at 360 days＇ follow-up and 120 days after treatment; there was no difference in the blood IgM level between the two groups （P〉0.05） in the treatment of 360 days＇ follow-up, IgM in the treatment group higher than the control group in the treatment of 120 days （P〈 0.05）, IgM in the control group compared with before treatment in 120 days of follow-up, there was no statisti- cal difference（P〉0.05）, in 360 days of follow-up higher than before treatment（P〈0.01）. There were no differences in blood IgG between the two groups for 120 days after treatment （P〉0.05）; the control group in IgG higher than the treatment group in 360 days of follow-up, there was statistical difference （P〈0.01）, both groups compared with be- fore treatment in IgM in 120 days of treatment, there were no statistical diffemces （P〉0.05）. IgE in both groups in 120 days of treatment, there were no satistical

关 键 词：支气管哮喘缓解期 B淋巴细胞 固本化痰法 

分 类 号：R259[医药卫生—中西医结合]