VEGF在脊髓型颈椎病动物模型椎间盘组织中的表达及意义  

Expression and Meaning of VEGF in Intervertebral Disc Tissue of Animal Model with Cervical Spondylotic Myelopathy

作　　者：樊成虎[1] 唐晓栋[1] 肖正军[2] 兰晓飞[2] 

机构地区：[1]甘肃省中医院,甘肃兰州730050 [2]甘肃中医药大学

出　　处：《西部中医药》2016年第11期132-134,共3页Western Journal of Traditional Chinese Medicine

基　　金：兰州市科技局项目(编号2011-2-35)

摘　　要：目的:探讨血管内皮生长因子(VEGF)在脊髓型颈椎病动物模型椎间盘组织中的表达及意义。方法:将脊髓型颈椎病大鼠模型中取得的椎间盘组织(造模组)进行HE染色及VEGF免疫组化检测,并与正常组作对照分析。结果:造模组大鼠颈椎间盘中髓核和纤维环VEGF的含量为74.10%和5.72%,分别高于对照组大鼠的28.40%和4.70%,2组比较差异有统计学意义(P<0.01)。结论:脊髓型颈椎病病变椎间盘内可诱导产生VEGF,提示VEGF可能通过促进新生血管的发生、发展,在退变的椎间盘组织中发挥作用。Objective： To explore the expression and meaning of VEGF in intervertebral disc tissue of animal model with cervical spondylotic myelopathy（CSM）. Methods： intervertebral tissue（ the model group） was stained by HE and detected by VEGF IHC got from animal model with cervical CSM, and analyzed as the control（ the normal） group. Results： The VEGF contents of nucleus pulposus and fiber ring of cervical intervertebral disc in the model group were 74.10% and 5.72%, they were higher than those of the control group （28.40% and 4.70%）. The difference between two groups was statistical significance （P〈0.01）.Conclusion： Intervertebral disc tissue of CSM can produce VEGF, it means that VEGF can play a role in intervertebral disc degeneration by promoting new vessels production and development.

关 键 词：脊髓型颈椎病 组织学 免疫组织化学 血管内皮生长因子 

分 类 号：R681.5[医药卫生—骨科学]