口服聚乙二醇溶液前或后吞服比沙可啶清洁肠道对CT结肠成像的影响研究  

Effect on colorectal cleansing of CT colonography with gulping down bisacodyl before or after oral taking polyethylene glycol

作　　者：陈志远[1] 郭红梅 田序伟[3] 罗明月[1] 段侪杰[4] Wenli Cai 邱建平[1] 

机构地区：[1]中山大学附属第六医院放射科,广州510655 [2]巴音郭楞蒙古自治州人民医院CT和MR科,新疆库尔勒841000 [3]喀什地区第一人民医院影像中心,新疆喀什844000 [4]清华大学深圳研究生院生物医学工程研究中心,广东深圳518055 [5]哈佛大学医学院麻州总医院放射科,麻州波士顿02114

出　　处：《重庆医学》2016年第36期5059-5062,共4页Chongqing medicine

基　　金：国家自然科学基金资助项目(81230035);广东省科技计划项目(2013B051000016);新疆维吾尔自治区自然科学基金项目(2016D01C027)

摘　　要：目的比较口服2L聚乙二醇前或后1h吞服10mg比沙可啶对CT结肠成像结直肠清洁的差异。方法 40例知情同意本研究的参与者分成A组、B组,每组20例。CT结肠成像检查前1d,A组3餐前口服40%W/V硫酸钡20mL,晚餐后口服溶解于250mL水之60%泛影葡胺20mL,口服2L聚乙二醇电解质液前1h吞服10mg比沙可啶肠溶片。B组口服2L聚乙二醇电解质液后1h吞服10mg比沙可啶肠溶片,其余同A组。统计分析两组结直肠粪块、肠液的清洁效果及存留肠液的CT值。结果 A组结直肠粪块清洁效果评分(1.96±0.11)分低于B组(2.01±0.12)分,结直肠粪块清洁效果好的肠段(87/120,72.50%)高于B组(83/120,69.17%),差异均无统计学意义(P>0.05)。A组结直肠肠液清洁效果评分(1.50±0.06)分低于B组(1.53±0.06)分,结直肠肠液清洁效果好的肠段(113/120,94.17%)高于B组(111/120,92.50%),差异均无统计学意义(P>0.05)。A组结直肠存留肠液的CT值(729±29)HU高于B组(653±25)HU,差异有统计学意义(P<0.05)。结论口服2L聚乙二醇前或后1h吞服10mg比沙可啶不影响结直肠粪块、肠液的清洁效果,但是前者对结直肠肠液的清洁效果更佳,有利于CT结肠成像检出结直肠息肉。Objective To comparative study the effect on colorectal cleansing of CT colonography with gulping down 10 mg bisacodyl before or 1 h after oral taking 2 liter polyethylene glycol .Methods Forty participants with informed consent were appor‐tioned to group A ,group B randomly ,20 cases in each group .On the day before CT colonography ,participants in group A oral took 20 mL of 40% W/V barium sulfate prior to 3 mealtime ,and 20 mL of 60% diatrizoate meglumine diluted in 250 mL of water after supper ,then gulped down 10 mg bisacodyl enteric‐coated tablets 1 hour before oral taking 2 liter polyethylene glycol electrolyte so‐lution .Participants in group B were the same as that in group A ,with the exception of gulping down 10 mg bisacodyl enteric‐coated tablets 1 hour after oral taking 2 liter polyethylene glycol electrolyte solution .Cleansing efficacy of stool and fluid ,and attenuation value of remainder fluid between the two groups were analyzed statistically .Results In group A ,score of cleansing efficacy of stool （1 .96 ± 0 .11） was lower than that in group B （2 .01 ± 0 .12） ,segments with good cleansing efficacy of stool （87/120 segments , 72 .50% ） was higher than that in group B （83/120 segments ,69 .17% ） ,the difference was not statistically significant （P〉0 .05） .In group A ,score of cleansing efficacy of fluid （1 .50 ± 0 .06） was lower than that in group B （1 .53 ± 0 .06） ,segments with good cleansing efficacy of fluid（113/120 segments ,94 .17% ） was higher than that in group B （111/120 segments ,92 .50% ） ,the differ‐ence was not statistically significant （P〉0 .05） .Attenuation value of remainder fluid [（729 ± 29）HU ] in group A was higher than that in group B[（653 ± 25）HU] ,the difference was statistically significant（P〈0 .05） .Conclusion Gulping down 10 mg Bisacodyl before or after oral taking 2 liter polyethylene glycol has no effect on cleansing of stool and fluid ,with good cleansing efficacy .The former has better cleansing

关 键 词：结直肠肿瘤 筛查 CT结肠成像 聚乙二醇 比沙可啶 

分 类 号：R816.5[医药卫生—放射医学]