阿托伐他汀强化疗法对高血压并发ST段抬高急性心肌梗死患者心脏功能与Lp-PLA2影响的研究  

Effect of atorvastatin intensive therapy on cardiac function and Lp-PLA2 in patients with hypertension complicated with ST segment elevation acute myocardial infarction

作　　者：张颖[1] 魏简汇[1] 翟保同[1] 郑芝欣[1] 

机构地区：[1]郑州大学附属医院南阳市中心医院西药科,河南南阳473000

出　　处：《重庆医学》2016年第36期5098-5100,共3页Chongqing medicine

摘　　要：目的探讨阿托伐他汀强化疗法对高血压并发ST段抬高急性心肌梗死患者心脏功能与脂蛋白磷脂酶A2(LpPLA2)的影响。方法选取2014年6月至2016年4月该院收治的高血压并发ST段抬高急性心肌梗死患者78例,依据随机数表法分为观察组(阿托伐他汀强化疗法)和对照组(常规治疗),比较两组患者治疗前后的血压、血脂、Lp-PLA2、心功能变化。结果治疗前,两组患者的血压、血脂指标差异无统计学意义(P>0.05);治疗后,两组患者的收缩压(SBP)、舒张压(DBP)、低密度脂蛋白胆固醇(LDL-C)明显降低,高密度脂蛋白胆固醇(HDL-C)显著升高,且观察组患者的SBP、HDL-C、LDL-C与对照组比较差异有统计学意义(P<0.05)。治疗前,两组患者的Lp-PLA2差异无统计学意义(P>0.05);治疗后,两组患者的Lp-PLA2均明显降低,且观察组变化幅度更大(P<0.05)。治疗前,两组患者的心功能指标差异无统计学意义(P>0.05);治疗后,观察组患者的左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)明显降低,左室射血分数(LVEF)、一氧化碳(CO)、心脏指数(CI)显著升高,与对照组比较差异有统计学意义(P<0.05)。结论阿托伐他汀强化疗法能够明显降低高血压并发ST段抬高急性心肌梗死患者血压及Lp-PLA2水平,改善患者心脏功能,值得临床推广。Objective To investigate the effect of atorvastatin intensive therapy on cardiac function and lipoprotein phospho‐lipase A2 （Lp‐PLA2） in patients with hypertension complicated with ST segment elevation acute myocardial infarction .Methods Totally 78 patients with hypertension complicated with ST segment elevation acute myocardial infarction from June 2014 to April 2016 in our hospital patients ,according to the random number table method divided into observation group （atorvastatin therapy ） and control group （routine treatment） .The changes of blood pressure ,blood lipid ,Lp‐PLA2 ,cardiac function of two groups were compared before and after treatment .Results Before treatment ,there was no significant difference in blood pressure and blood lipid between the two groups （P〉0 .05） .After treatment ,the two groups of patients with SBP ,DBP ,LDL‐C significantly decreased , HDL‐C significantly increased ,and compared with the control group ,the SBP ,HDL‐C ,LDL‐C in the observation group were signif‐icantly different （P〈0 .05） .Before treatment ,there was no significant difference in Lp‐PLA2 between the two groups（P〉0 .05） . After treatment ,the two groups of patients with Lp‐PLA2 were significantly reduced ,and the observation group was significantly greater （P〈0 .05） .Before treatment ,there was no significant difference in cardiac function between the two groups （P〉0 .05） .Af‐ter treatment ,the observation group of patients with LVESD ,LVEDD significantly decreased ,LVEF ,CO ,CI significantly in‐creased ,compared with the control group ,the difference was statistically significant （P〈0 .05） .Conclusion Atorvastatin intensive therapy can significantly reduce high blood pressure acute ST segment elevated blood pressure and Lp‐PLA2 levels in patients with acute myocardial infarction and improve cardiac function ,worthy of promotion .

关 键 词：阿托伐他汀 高血压 ST段抬高 心肌梗死 LP-PLA2 

分 类 号：R542.22[医药卫生—心血管疾病] R544.1[医药卫生—内科学]