多囊卵巢综合征患者血清鸢尾素水平及其与胰岛素抵抗的关系  

Association of serum irisin and insulin resistant in female with polycystic ovary syndrome

作　　者：杨若梅[1] 魏晓[1] 王成潘 李志勇[1] 唐倩[1] 黄丹[1] 杨刚毅[2] 李伶[3] 

机构地区：[1]重庆医科大学附属永川医院内分泌科,重庆402160 [2]重庆医科大学附属第二医院内分泌科,重庆400010 [3]重庆医科大学检验医学院临床检验诊断学教育部重点实验室,重庆400016

出　　处：《重庆医科大学学报》2016年第11期1163-1167,共5页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(编号:81070640;30971388)

摘　　要：目的:探讨多囊卵巢综合征(polycystic ovarian syndrome,PCOS)患者血清鸢尾素(irisin)水平及其与胰岛素抵抗(insulin resistance,IR)的关系。方法:纳入PCOS患者60例及健康女性志愿者80例,测量血清激素、血清鸢尾素浓度等,用HOMA稳态模型抵抗指数评估IR,胰岛β细胞功能指数(HOMA-β)、口服葡萄糖耐量试验(oral glucose tolerance test,OGTT)30 min胰岛素血糖与空腹胰岛素血糖差值的比(△Ins30/△Glu30)、胰岛素与血糖比值曲线下面积(AUCIns/Glu)评估β细胞功能,以及采用Pearson’s相关和多元逐步线性回归分析血清鸢尾素与IR的关系。结果:PCOS患者血清鸢尾素较对照组升高(P<0.05);血清鸢尾素水平与体质指数(r=0.381,P=0.003)、空腹血糖(r=0.565,P=0.000)、空腹胰岛素(r=0.551,P=0.000)、餐后2 h胰岛素(r=0.299,P=0.020)、LH/FSH(r=0.802,P=0.000)、孕酮(r=0.349,P=0.006)、TG(r=0.306,P=0.018)、HOMA-IR(r=0.632,P=0.000)、AUCIns/Glu(r=0.317,P=0.014)呈正相关;多元逐步回归分析显示PCOS患者血清鸢尾素与HOMA-IR相关,与β细胞功能(HOMA-β,△Ins30/△Glu30,AUCIns/Glu)无相关(F=169.05,R2=0.945,P=0.00)。结论:PCOS患者血清鸢尾素水平升高,可能在IR的发病机制中起作用。Objective：To investigate the serum irisin levels and its association with insulin resistance（IR）in patients with polycystic ovary syndrome（PCOS）. Methods：Sixty patients diagnosed as PCOS and eighty healthy female volunteers were enrolled in this study.Serum hormone and irisin levels were measured. Homeostasis model of insulin resistance（HOMA-IR）was performed to evaluate IR,and HOMA-β,△Ins30/△Glu30,AUCIns/Gluwere used to assess β-cell function,and the relation between irisin and IR was analyzed by Pearson＇s correlation and multiple stepwise regression. Results：The level of serum irisin in patients with PCOS was higher than that of control group（P〈0.05）. Serum irisin levels were positively correlated with BMI（r=0.381,P=0.003）,fasting blood glucose（r=0.565,P=0.000）,fasting insulin（r=0.551,P=0.000）,2-hour post-load insulin（r =0.299,P =0.020）,LH/FSH（r =0.802,P =0.000）,progesterone（r=0.349,P=0.006）,TG（r=0.306,P=0.018）,HOMA-IR（r=0.632,P=0.000）and AUCIns/Glu（r=0.317,P=0.014）. Multiple stepwise regression analysis indicated that irisin was associated with HOMA-IR,but had no correlation with β-cell function（HOMA-β,△Ins30/△Glu30,AUCIns/Glu）in PCOS patients（F=169.05,R2=0.945,P=0.000）. Conclusion：Serum irisin is elevated in patients with PCOS and may play a role in the pathogenesis of IR.

关 键 词：多囊卵巢综合征 鸢尾素 胰岛素抵抗 

分 类 号：R588.6[医药卫生—内分泌]